Polycythemia is a condition of the bone marrow. It makes too many red blood cells and platelets. Sometimes, white blood cells are affected. The increase of blood cells can make the blood thicken and clot.
Early treatment lowers the risk of serious problems.
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This condition is caused by changes to a gene. It is not clear what causes this to happen.
Polycythemia is more common in men and people aged 40 years or older. The risk is higher in people of Ashkenazi Jewish decent.
Some people with polycythemia have no symptoms. Others may have symptoms such as:
Polycythemia is sometimes found during a routine blood test. The doctor will ask about symptoms and past health. A physical exam will be done.
Tests may include:
Treatment depends on how severe the disease is. The goal is to manage the disease and problems linked to it—such as blood clots. For some, a combination of treatments works best.
Options may be:
There are no guidelines prevent polycythemia.
American Society of Hematology
National Heart, Lung, and Blood Institute
Mesa RA. Refining the management of polycythemia vera. Clin Adv Hematol Oncol. 2018;16(9):587-589.
Polycythemia vera. EBSCO DynaMed website. Available at: https://www.dynamed.com/condition/polycythemia-vera. Accessed September 10, 2021.
Polycythemia vera. Merck Manual Professional Version website. Available at: https://www.merckmanuals.com/professional/hematology-and-oncology/myeloproliferative-disorders/polycythemia-vera. Accessed September 10, 2021.
Polycythemia vera. National Heart, Lung, and Blood Institute website. Available at: https://www.nhlbi.nih.gov/health-topics/polycythemia-vera. Accessed September 10, 2021.
Last reviewed July 2021 by EBSCO Medical Review Board Nicole Meregian, PA Last Updated: 9/10/2021