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Introduction

Inosine is a compound in the body that helps create energy. It has been used to improve athletic performance and heart function. Inosine can be taken as a pill.

Dosages

2 to 4 grams once daily

What Research Shows

Not Enough Data to Assess

  • Multiple sclerosis A1-A3

Editorial process and description of evidence categories can be found at EBSCO NAT Editorial Process.

Safety Notes

It is likely safe for most adults to take inosine in small doses for a short time, but kidney stones are possible. B1 Not enough studies have been done to say whether it is safe to take for a long period. It is also not known whether it is safe to take by women who are pregnant or breastfeeding.

Interactions

Talk to your doctor about any supplements or therapy you would like to use. Some can interfere with treatment or make conditions worse.

 

References

A. Multiple Sclerosis

A1. Markowitz CE, Spitsin S, et al. The treatment of multiple sclerosis with inosine. J Altern Complement Med. 2009 Jun;15(6):619-625.

A2. Gonsette RE, Sindic C, et al. Boosting endogenous neuroprotection in multiple sclerosis: the Association of Inosine and Interferon beta in relapsing- remitting Multiple Sclerosis (ASIIMS) trial. Mult Scler. 2010 Apr;16(4):455-462.

A3. Muñoz García D, Midaglia L, et al. Associated Inosine to interferon: results of a clinical trial in multiple sclerosis. Acta Neurol Scand. 2015 Jun;131(6):405-410.

B. Safety

B1. Markowitz CE, Spitsin S, et al. The treatment of multiple sclerosis with inosine. J Altern Complement Med. 2009 Jun;15(6):619-625.

Last reviewed February 2020 by EBSCO NAT Review Board Eric Hurwitz, DC  Last Updated: 5/27/2020