Rotigotine transdermal patches are used to treat the signs and symptoms of Parkinson's disease (PD; a disorder of the nervous system that causes difficulties with movement, muscle control, and balance) including shaking of parts of the body, stiffness, slowed movements, and problems with balance. Rotigotine transdermal patches are also used to treat restless legs syndrome (RLS or Ekbom syndrome; a condition that causes discomfort in the legs and a strong urge to move the legs, especially at night and when sitting or lying down). Rotigotine is in a class of medications called dopamine agonists. It works by acting in place of dopamine, a natural substance produced in the brain that is needed to control movement.
Transdermal rotigotine comes as a patch to apply to the skin. It is usually applied once a day. Apply the rotigotine patch at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Use rotigotine exactly as directed.
Your doctor will probably start you on a low dose of rotigotine and gradually increase your dose, not more often than once a week.
Rotigotine controls the symptoms of Parkinson's disease and restless legs syndrome but does not cure them. It may take several weeks before you feel the full benefit of rotigotine. Continue to use rotigotine patches even if you feel well. Do not stop using rotigotine transdermal patches without talking to your doctor. If you suddenly stop using rotigotine patches, you may experience fever, muscle stiffness, change in consciousness, or other symptoms. Your doctor will probably decrease your dose gradually.
Apply the patch to an area on the stomach, thigh, hip, flank (side of the body between the ribs and pelvis), shoulder, or upper arm. The area of skin should be clean, dry and healthy. Do not apply the patch to skin that is oily, red, irritated, or injured. Do not use creams, lotions, ointments, oils, or powders on the area of skin where the patch will be placed. Do not apply the patch to skin folds and areas of skin that could be under a waistband or rubbed by tight clothing. If the patch is to be applied to a hairy area, shave the area at least 3 days before applying the patch. Select a different area of skin each day such as changing from the right side to the left side or by moving from the upper body to the lower body. Do not apply the rotigotine patch to the same area of skin more often than once every 14 days.
While you are wearing the patch, keep the area away from other sources of heat such as heating pads, electric blankets and heated waterbeds; or direct sunlight. Do not take a hot bath or use a sauna.
Be careful to not dislodge the patch during bathing or physical activity. If the edges of the patch lift, use a bandage tape to re-secure it to the skin. If the patch falls off, apply a new patch to a different place on your skin for the rest of the day. The following day, remove that patch and apply a new patch at the usual time.
If the area of skin that was covered by the patch becomes irritated or develops a rash, do not expose this area to direct sunlight until the skin heals. Exposure of this area to sun could cause changes in your skin color.
Do not cut or damage a rotigotine patch.
To apply the patch, follow these steps:
This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.
Before using the rotigotine patch,
Unless your doctor tells you otherwise, continue your normal diet.
Apply the missed dose (patch) as soon as you remember it, then apply a new patch at the usual time the next day. Do not apply an extra patch to make up for a missed dose.
Rotigotine may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
Some side effects can be serious. If you experience any of these symptoms or those listed in the SPECIAL PRECAUTIONS section, call your doctor immediately:
Some people who took medications such as rotigotine to treat Parkinson's disease developed gambling problems, increased sexual urges, or other intense urges. There is not enough information to tell whether the people developed these problems because they took the medication or for other reasons. Call your doctor if you have an urge to gamble, sexual urges or other urges that are difficult to control. Tell your family members about these risks so that they can call the doctor even if you do not realize that these urges have become a problem.
People who have Parkinson's disease may have a greater risk of developing melanoma (a type of skin cancer) than people who do not have Parkinson's disease. There is not enough information to tell whether medications used to treat Parkinson's disease such as rotigotine increase the risk of developing skin cancer. You should have regular skin examinations to check for melanoma while you are taking rotigotine even if you do not have Parkinson's disease. Talk to your doctor about the risk of taking rotigotine.
Rotigotine may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.
If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online ( Web Site ) or by phone (1-800-332-1088).
Keep this medication in the original pouch it came in, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).
Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website ( Web Site) for more information if you do not have access to a take-back program.
It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. Web Site
If someone applies extra rotigotine patches, remove the patches. Then call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.
Symptoms of overdose may include:
Keep all appointments with your doctor.
Do not let anyone else use your medication. Ask your pharmacist any questions you have about refilling your prescription.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
AHFS® Consumer Medication Information. © Copyright, The American Society of Health-System Pharmacists, Inc., 7272 Wisconsin Avenue, Bethesda, Maryland. All Rights Reserved. Duplication for commercial use must be authorized by ASHP.
Selected Revisions: July 15, 2018.