Aprepitant injection and fosaprepitant injection are used along with other medications to prevent nausea and vomiting in adults that may occur within 24 hours or several days after receiving certain cancer chemotherapy treatments. Fosaprepitant injection can also be used in children 6 months of age and older. Aprepitant and fosaprepitant injections arenotused to treat nausea and vomiting that you already have. Aprepitant and fosaprepitant injections are in a class of medications called antiemetics. They work by blocking the action of neurokinin, a natural substance in the brain that causes nausea and vomiting.
Aprepitant injection comes as an emulsion (liquid) and fosaprepitant injection comes as a powder to be mixed with liquid and given intravenously (into a vein) by a doctor or nurse in a medical facility. Aprepitant injection or fosaprepitant injection is usually given as a one-time dose on day 1 of a chemotherapy treatment cycle, finishing about 30 minutes before the start of chemotherapy. For children and teenagers receiving aprepitant injection and adults receiving fosaprepitant with certain chemotherapy treatments, oral aprepitant may also be given on days 2 and 3 of the chemotherapy treatment cycle.
You may experience a reaction during or shortly after you receive a dose of aprepitant injection or fosaprepitant injection. Tell your doctor immediately if you experience any of these symptoms during or shortly after you receive treatment: swelling around your eyes, rash, hives, itching, redness, flushing, difficulty breathing or swallowing, feeling dizzy or faint, or fast or weak heartbeat. Your doctor will probably stop the infusion, and may treat the reaction with other medications.
Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.
This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.
Before using aprepitant or fosaprepitant injection,
Unless your doctor tells you otherwise, continue your normal diet.
Aprepitant injection and fosaprepitant injection may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately:
Aprepitant and fosaprepitant may cause other side effects. Call your doctor if you have any unusual problems while using this medication.
If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online ( Web Site ) or by phone (1-800-332-1088).
Keep all appointments with your doctor.
Do not let anyone else use your medication. Ask your pharmacist any questions you have about refilling your prescription.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
AHFS® Consumer Medication Information. © Copyright, The American Society of Health-System Pharmacists, Inc., 7272 Wisconsin Avenue, Bethesda, Maryland. All Rights Reserved. Duplication for commercial use must be authorized by ASHP.
Selected Revisions: June 15, 2019.