Nephrotic syndrome is a group of changes affecting the kidneys. These may involve:
- High amounts of protein in the urine
- Swelling in the body—mainly in the feet and legs
- Low levels of a protein called albumin in the blood
- High cholesterol in the blood
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The kidneys filter waste from the blood and make urine. This problem happens when tiny filters in the kidneys leak too much protein into urine.
In most children, the cause is not known. In others, the most common cause is minimal change disease. This is damage to the filters due to things like infections, tumors, allergic reactions, and certain medicines.
Other health problems that can damage the kidneys can also lead to nephrotic syndrome.
This problem can affect children of any age. It is more common in boys. Other things that may raise the risk are:
Problems may be:
- Lack of energy
- Pale skin
- Lack of hunger
- Foamy urine
- Swelling of feet, ankles, and legs and less often the belly, hands, and face
- Weight gain
- Mood changes
- Breathing problems
There may be times when the syndrome does not cause problems. There may be other times when symptoms are more active.
The doctor will ask about your child’s symptoms and health history. A physical exam will be done. You will be checked for swelling in the body. This may be enough to suspect the diagnosis.
Blood and urine tests will be done to look at protein levels. This can confirm the diagnosis.
Any underlying causes will need to be treated. Care will be given by a doctor who treats the kidneys.
Nephrotic syndrome often goes away on its own. Some treatment options are:
Salt, fats, cholesterol, and fluids may need to be limited. This can help ease problems, such as swelling.
Medicine may be given to:
- Control the immune system and improve kidney function—corticosteroids
- Remove extra fluid—diuretics
- Lower blood pressure
Medicines that may be causing harm to the kidneys may also need to be stopped or changed.
There are known methods to prevent this health problem.
Kids Health—Nemours Foundation
National Institute of Diabetes and Digestive and Kidney Disorders
Caring for Kids—Canadian Paediatric Society
The Kidney Foundation of Canada
Childhood nephrotic syndrome. National Institute of Diabetes and Digestive and Kidney Diseases website. Available at: https://www.niddk.nih.gov/health-information/kidney-disease/children/childhood-nephrotic-syndrome. Accessed August 31, 2021.
Childhood nephrotic syndrome. National Kidney Foundation website. Available at: https://www.kidney.org/atoz/content/childns. Accessed August 31, 2021.
Nephrotic syndrome. Kids Health—Nemours Foundation website. Available at: http://kidshealth.org/en/parents/nephrotic-syndrome.html. Accessed August 31, 2021.
Nephrotic syndrome in children. Children’s Hospital of Philadelphia website. Available at: http://www.chop.edu/conditions-diseases/nephrotic-syndrome-children. Accessed August 31, 2021.
Nephrotic syndrome in children. EBSCO DynaMed website. Available at: https://www.dynamed.com/condition/nephrotic-syndrome-in-children-21. Accessed August 31, 2021.
Last reviewed July 2021 by EBSCO Medical Review Board Kari Kuenn, MD Last Updated: 8/31/2021