Risk Factors for Uterine (Endometrial) Cancer
by Debra Wood, RN
A risk factor is something that increases your chances of developing cancer.
It is possible to develop uterine cancer with or without the risk factors listed below. In fact, the majority of women who are diagnosed with uterine cancer have no known risk factors for the disease. However, the more risk factors you have, the greater your likelihood of developing uterine or endometrial cancer. If you have a number of risk factors, ask your doctor what you can do to reduce your risk.
Many risk factors associated with uterine cancer are associated with increased levels of the hormone estrogen. The body normally produces estrogen and progesterone, and keeps these hormones in balance. If something causes estrogen levels to rise, the woman may be at increased risk of uterine cancer.
Risk factors for uterine or endometrial cancer include the following:
Excess weight may increase your risk of uterine cancer, especially if you go through menopause early, prior to age 45. Obese may alter hormone levels, increasing exposure of the uterine lining to estrogen.
Medical Conditions and Treatments
Several medical conditions and treatments are associated with increased risk of uterine cancer. These include:
Uterine cancer occurs more frequently in older women. Eighty percent of women have gone through menopause. Only 5% of cases are diagnosed in women younger than 40, and these women usually have polycystic ovary syndrome.
Reproductive History TOP
Women who have never been pregnant are a greater risk for uterine cancer. Progesterone levels increase during pregnancy, which may offer a protective benefit. Menstruating at an early age or a late menopause is also associated with increased risk. Both of these events increase a woman’s lifetime exposure to estrogen.
Bast R. Cancer Medicine. 5th ed. Hamilton, Ontario: BC Decker Inc; 2000.
Endometrial cancer. National Cancer Institute website. Available at:
...(Click grey area to select URL)
Accessed August 31, 2009.
Rakel R. Conn's Current Therapy 2002. 54th ed. St. Louis, MO: WB Saunders Company; 2002: 1094-1096.
What are the risk factors for endometrial cancer? American Cancer Society website. Available at:
...(Click grey area to select URL)
Accessed December 20, 2014.
8/31/2009 DynaMed Plus Systematic Literature Surveillance http://www.dynamed.com/topics/dmp~AN~T113952/Endometrial-cancer: Thomas CC, Wingo PA, Dolan MS, Lee NC, Richardson LC. Endometrial cancer risk among younger, overweight women. Obstet Gynecol. 2009;114:22-27.
Last reviewed December 2015 by Mohei Abouzied, MD
Last Updated: 12/20/2014
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