Some people may need surgery when other methods do not help. It may also be done in people who have uncontrolled bleeding or a perforation. Options may be:

  • Endoscopy—uses a small tube with a light and camera to view bleeding and apply heat to stop it
  • Partial gastrectomy—removes part of the stomach
  • Vagotomy—cuts the vagus nerve to reduce stomach acid
  • Gastroduodenostomy—creates a new connection between the stomach and the first part of the small intestine

National Institute for Health and Clinical Excellence (NICE). Dyspepsia and gastro-esophageal reflux disease: Investigation and management of dyspepsia, symptoms suggestive of gastro-esophageal reflux disease, or both. NICE 2014 Sep:CG184.

Peptic ulcer disease. EBSCO DynaMed website. Available at: Updated April 2, 2018. Accessed February 3, 2020.

Peptic ulcer disease. Merck Manual Professional Version website. Available at: Updated January 2020. Accessed February 3, 2020.

Peptic ulcers (stomach ulcers). National Institute of Diabetes and Digestive and Kidney Diseases website. Available at: Updated November 2014. Accessed February 3, 2020.

Last reviewed November 2019 by EBSCO Medical Review Board Daniel A. Ostrovsky, MD  Last Updated: 2/9/2021