Bromelaina - Posible Interacción de Ayuda
Vitamina K - Posible Reducción Nutricional

También consulte Antibióticos (General)

La amoxicilina pertenece a al familia del antibiótico penicilina , pero ha sido modificada para tener un espectro más amplio de efecto.

Posible Interacción Útil

Según dos estudios, la bromelaina complementaria (del tallo de la piña) puede aumentar la absorción de amoxicilina.1, 2 Este efecto podría ayudar al antibiótico a funcionar de mejor manera.

Posible Reducción Nutricional

Existen preocupaciones de que el tratamiento antibiótico podría reducir los niveles de vitamina K en el cuerpo. Sin embargo, este efecto parece ser ligero, y solamente significativo, si a caso, en individuos que ya presentan deficiencias considerables de vitamina K.3 – 6


1. Tinozzi S and Venegoni A. Effect of bromelain on serum and tissue levels of amoxicillin. Drugs Exp Clin Res 4: 39 - 44, 1978.

2. Luerti M and Vignali M. Influence of bromelain on penetration of antibiotics in uterus, salpinx and ovary. Drugs Exp Clin Res 4: 45 - 48, 1978.

3. Cohen H, Scott SD, Mackie IJ, et al. The development of hypoprothrombinaemia following antibiotic therapy in malnourished patients with low serum vitamin K 1 levels. Br J Haematol 68: 63 - 66, 1988.

4. Conly J and Stein K. Reduction of vitamin K 2 concentrations in human liver associated with the use of broad spectrum antimicrobials. Clin Invest Med 17: 531 - 539, 1994.

5. Shearer MJ, Bechtold H, Andrassy K, et al. Mechanism of cephalosporin-induced hypoprothrombinemia: relation to cephalosporin side chain, vitamin K metabolism, and vitamin K status. J Clin Pharmacol 28: 88 - 95, 1988.

6. Goss TF, Walawander CA, Grasela TH, et al. Prospective evaluation of risk factors for antibiotic-associated bleeding in critically ill patients. Farmacoterapia 12: 283 - 291, 1992.

Ultima revisión agosto 2013 por EBSCO CAM Review Board
Last Updated: 8/22/2013

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