(Hemophilia A—Factor VIII Deficiency; Classic Hemophilia; Hemophilia B—Factor IX Deficiency; Christmas Disease)
by Rosalyn Carson-DeWitt, MD
Hemophilia is a group of bleeding disorders. Certain blood clotting factors are too low or missing. These help to stop bleeding.
The most common types are:
A faulty gene on a certain DNA strand causes hemophilia. Females carry 2 copies of the strand. If one is faulty, the other one takes over. The faulty gene can pass to their children. If so, the female child will carry the gene. If it passes to the male, they will get the disease because they carry one copy of the strand.
It’s possible for a female to get the disease. They would have to get the faulty gene from both parents.
Hemophilia mainly happens in males. Your chances are higher if it runs in your family.
Symptoms differ based on severity. Bleeding is the main issue. It’s often related to an injury or surgery. In babies, the disease may not show until they are mobile. Milder versions may not be noticed until later in life.
The most common are:
The doctor will ask about your symptoms and health history. Your answers and a physical exam may point to hemophilia. You may also have blood tests to see how well your blood clots. These tests will also look for low or missing clotting factors.
Care may involve:
An injection replaces the missing factor. It’s based on the type of disease you have. You will watch your levels with a test. The dose is used when the levels drop too low. If you have a high risk of bleeding for any reason, you take a dose ahead of time.
This factor can be given at home. You and others will learn how to give it. It’s used at the first signs of bleeding. This can help avert a crisis. People with serious forms sometimes need doses at scheduled times.
Some people may need more than one clotting factor.
Mild hemophilia A is treated with medicine. The medicine causes the release of blood factor. It’s stored within the lining of the blood vessels.
To lower your chances of bleeding:
If the disease runs in your family, talk to your doctor about genetic testing.
American Society of Hematology
National Hemophilia Foundation
Canadian Hemophilia Society
Caring for Kids—Canadian Paediatric Society
What is hemophilia? National Heart, Lung, and Blood Institute website. Available at: https://www.nhlbi.nih.gov/health-topics/hemophilia. Accessed July 17, 2018.
Hemophilia A. EBSCO DynaMed Plus website. Available at: http://www.dynamed.com/topics/dmp~AN~T115190/Hemophilia-A . Updated May 19, 2017. Accessed July 17, 2018.
Hemophilia B. EBSCO DynaMed Plus website. Available at: http://www.dynamed.com/topics/dmp~AN~T113770/Hemophilia-B . Updated February 8, 2018. Accessed July 17, 2018.
10/24/2012 DynaMed's Systematic Literature Surveillance. http://www.dynamed.com/topics/dmp~AN~T113770/Hemophilia-B : Broderick CR, Herbert RD, Latimer J, et al. Association between physical activity and risk of bleeding in children with hemophilia. JAMA. 2012;308(14):1452-1459.
Last reviewed May 2018 by EBSCO Medical Review Board Michael Fucci, DO, FACC
Last Updated: 7/17/2018
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