Active Hexose Correlated Compound


Active Hexose Correlated Compound (AHCC) is a supplement made from certain mushrooms, such as shiitake. It has been used to help ease symptoms caused by chemotherapy. It can be taken as a powder or a pill.


2 to 6 grams once daily

What Research Shows

May Be Effective

  • Pancreatic cancer treatment —may improve symptoms of taste disorder caused by chemotherapyA1

Editorial process and description of evidence categories can be found at EBSCO NAT Editorial Process.

Safety Notes

It is likely safe to take small amounts of AHCC. Not enough studies have been done to say whether it is safe to use for a long period.


Talk to your doctor about any supplements or therapy you would like to use. Some can interfere with treatment or make conditions worse.




A1. 1. Yanagimoto H, Satoi S, et al. Alleviating Effect of Active Hexose Correlated Compound (AHCC) on Chemotherapy-Related Adverse Events in Patients with Unresectable Pancreatic Ductal Adenocarcinoma. Nutr Cancer. 2016;68(2):234-240.

Last reviewed March 2019 by EBSCO NAT Review Board Eric Hurwitz, DC