Vaginal cancer is an uncommon disease in which cancer cells grow from the cells of the vaginal lining. The vagina is a tube that connects the vulva (external female genitals) to the cervix (lower end of the uterus). The vagina is also called the “birth canal.”
Cancer occurs when cells in the body (in this case, vaginal cells) divide without control or order. Normally, cells divide in a regulated manner. If cells keep dividing uncontrollably when new cells are not needed, a mass of tissue, called a growth or tumor, forms. The term cancer refers to malignant tumors, which can invade nearby tissue and spread to other parts of the body. A benign tumor does not invade or spread.
There are several types of vaginal cancer:
These risk factors increase your chance of developing vaginal cancer. Tell your doctor if you have any of these risk factors:
If you have any of these symptoms, do not assume it is due to vaginal cancer. These symptoms may be caused by other conditions. Tell your doctor if you have any of these:
Your doctor will ask about your symptoms and medical history and perform a physical exam, including a pelvic exam. You may be referred to a doctor who specializes in women’s health (a gynecologist).
Tests may include:
If cancer is found, additional tests are usually done to determine whether or not it has spread to other parts of the pelvis or elsewhere in the body. These tests may include:
Once vaginal cancer is found, staging tests are done to find out if the cancer has spread and, if so, to what parts of the body. Treatments for vaginal cancer depend on the stage of the cancer.
Talk with your doctor about the best treatment plan for you. Treatment options include:
Radiation therapy is the use of high-dose radiation to kill cancer cells and shrink tumors. Radiation is usually directed at the tumor from a source outside the body. In some cases, radioactive material may be temporarily placed near the tumor to expose the cancerous cells to a constant level of radiation. This is called an implant and generally requires a short hospital stay. Other radiation treatments are outpatient.
This involves the surgical removal of a cancerous tumor and nearby tissues, and possibly lymph nodes. Depending on how far the cancer has spread outside the vagina, the doctor may remove the vagina, cervix, uterus, and sometimes the bladder, rectum, and parts of the colon.
Chemotherapy is the use of drugs to kill cancer cells. This treatment may be given as a topical cream, pill, or intravenous injection. Except for topical creams, in which the drug is applied directly on the walls of the vagina, chemotherapy drugs enter the bloodstream and travel through the body killing mostly cancer cells, but also some healthy cells.
While a Pap smear is an effective screening tool for cervical cancer, it cannot be relied upon to detect vaginal cancer. However, regular gynecologic exams may reduce the risk of death from vaginal cancer by providing your doctor with the opportunity to detect it earlier. If you were exposed to DES in the womb, tell your doctor so that he can be more aware of your risk for vaginal cancer and take steps to closely monitor you.
There is a vaccine available, called Gardasil, that protects against four types of the human papillomaviruses (HPV). Since HPV is associated with certain types of cancer, the vaccine helps to prevent cancers of the cervix, vulva, and vagina.
American Cancer Society
Gynecologic Cancer Foundation
Canadian Cancer Society
Canadian Women's Health Network
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Last reviewed December 2011 by Igor Puzanov, MD
Last Updated: 12/30/2011