Wolff-Parkinson-White syndrome (WPW) is a disorder of the heart’s electrical activity. It causes the heart to beat with an irregular rhythm and faster than normal. This is called tachyarrhythmia.
In a normal heart, electrical signals that cause the heart to beat begin in the area known as the SA node, located in the right upper chamber (atrium) of the heart. The electrical signal goes from the SA node down to the AV (atrioventricular) node which is between the atria and the lower chambers of the heart (the ventricles). The AV node slows down the electrical impulse so that the ventricles have time to fill with blood before contracting.
In WPW, the electrical signals travel along an extra, abnormal pathway that go around the AV node. This causes the signals to be unregulated and to arrive at the ventricles too soon. The signals often alert the ventricles to contract abnormally. As a result, the heart beats much faster than normal.
The extra pathway is caused by abnormal growth of tissue that connects the heart’s chambers. This occurs in the embryo—during the first eight weeks after conception.
Electrical Conduction System of the Heart
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A risk factor is something that increases your chance of developing a disease or condition. There are no known risk factors for WPW syndrome.
Some people with WPW syndrome never have tachyarrhythmia and its associated symptoms. In those who do, symptoms usually begin between ages 11-50. The frequency and severity of the tachyarrhythmia varies from one person to another and may be associated with any or all of these symptoms:
In rare cases, a person will go into cardiac arrest (the heart stops pumping) and lose consciousness.
The doctor will ask about your symptoms and medical history, and perform a physical exam. If you are having a tachyarrhythmia due to WPW syndrome, you will have normal or low blood pressure and a heart rate of 150-250 beats per minute. (A normal heart rate is 60-100 beats per minute.)
If you are not having irregular heart rhythms during the exam, the results of the exam may be normal. In either case, an electrocardiogram (a test that records the heart's activity by measuring electrical currents through the skin) will usually show a “delta wave” that signals an extra electrical pathway.
Other tests may include:
The goal of treatment is to reduce or eliminate episodes of tachyarrhythmia and associated symptoms. If you do not have symptoms, treatment is usually not necessary.
If you do need treatment, it may include:
Antiarrhythmics may be given to coordinate your heart's electrical signals. This can control or prevent episodes of rapid heartbeat. However, you must take the medicine carefully because it can sometimes make an abnormal heart rhythm worse.
This is a procedure in which a catheter delivers energy at a particular radiofrequency to your heart. This destroys (ablates) the abnormal electrical pathway. In most cases, ablation is successful and ends the need to take medicine.
Open-heart surgery is done to destroy the abnormal pathway. However, this procedure is rarely done.
This is done in the case of cardiac arrest, which is rare. Defibrillation gives the heart a brief electric shock. This procedure converts a rapid, irregular heartbeat back into a normal heartbeat.
If you are diagnosed with WPW syndrome, follow your doctor's instructions.
There is no known way of preventing WPW syndrome. However, symptoms can be prevented with proper treatment.
American Heart Association
Heart Rhythm Society
Canadian Cardiovascular Society
Heart and Stroke Foundation of Canada
American Heart Association website. Available at:
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Heart Center Online website. Available at:
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The Merck Manual of Diagnosis and Therapy. Simon and Schuster; 1999.
Last reviewed December 2013 by Michael J. Fucci, DO
Last Updated: 1/14/2014