Acute tubular necrosis is damage to the tubule cells (tiny tube-shaped cells) in the kidney that results in acute kidney failure. This is a potentially serious condition that requires care from your doctor.
Acute tubular necrosis can be caused by:
A risk factor is something that increases your chance for getting a disease or condition. Risk factors that increase your chance of developing acute tubular necrosis include:
If you experience any of these symptoms, do not assume it is due to acute tubular necrosis. These symptoms may be caused by other, less serious health conditions. If you experience any one of them, see your physician.
Your doctor will ask about your symptoms and medical history. A physical exam will be done. Tests may include the following:
Talk with your doctor about the best treatment plan for you. In addition to good nutritional support, treatment options include the following:
Dialysis, in which a machine does the work of your kidneys by purging waste from your body.
Certain medications (eg, furosemide, bumetanide, mannitol, fenoldopam, auriculin anaritide, and synthetic atrial natriuretic peptide) may reduce the need for dialysis in certain people with acute tubular necrosis.
The following measures may help reduce your chances of developing acute tubular necrosis:
American Academy of Family Physicians
National Kidney and Urologic Diseases Information Clearinghouse
Canadian Institute for Health Information
Kidney Foundation of Canada
Acute tubular necrosis. EBSCO DynaMed website. Available at: http://www.ebscohost.com/dynamed . Updated June 14, 2010. Accessed November 1, 2012.
Choudhury D, Ahmed Z: Drug-associated renal dysfunction and injury. Nat Clin Pract Nephrol . 2006;2:80-91
Esson ML, Schrier RW. Diagnosis and treatment of acute tubular necrosis. Ann Intern Med . 2002;137:744-52.
Gill N, Nally JV Jr, Fatica RA. Renal failure secondary to acute tubular necrosis: epidemiology, diagnosis, and management. Chest . 2005;128:2847-2863.
Musso CG, Liakopoulos V, Ioannidis I, et al. Acute renal failure in the elderly: particular characteristics. Int Urol Nephrol . 2006;38:787-93
Tepel M, van der Giet M, Schwarzfeld C, et al. Prevention of radiographic-contrast reductions in renal function by acetylcysteine. N Engl J Med . 2000;343:1448-1457.
Last reviewed October 2012 by Adrienne Carmack, MD
Last Updated: 10/31/2012