by Rick Alan
Muscular dystrophy is a group of inherited, progressive muscle disorders. All forms cause progressive weakness and degeneration of the muscles that control movement. Some also affect the heart or other organs. Age of onset is between infancy to adulthood. The different forms include:
This condition is caused by defects in genes that control muscle development and function. In some cases, the genes are passed from parent to child. In other cases, the genetic mutation occurs spontaneously.
These factors increase your chance of developing muscular dystrophy. Tell your doctor if you have any of these risk factors:
Each type of muscular dystrophy has its own unique symptoms. For example, the muscles that are affected may differ depending the type.
Symptoms common to most forms of muscular dystrophy may include:
Severe Muscle Contraction of the Hand
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Symptoms specific to Duchenne and Becker dystrophy include:
Symptoms specific to myotonic muscular dystrophy include:
Symptoms usually become worse over time. In many forms, life expectancy is shortened.
The doctor will ask about your symptoms and medical history. A physical exam will be done.
Your blood may be tested for evidence of muscle damage
A muscle biopsy will identify the type of musciular dystrophy
Your muscles and nerves may be tested. This can be done with:
There is no cure for muscular dystrophy. However, treatment may help improve the symptoms.
Treatment may consist of:
Physical therapy and exercise can help prevent the muscles from permanently contracting and stiffening.
In earlier stages, wearing braces may improve your ability to move around. A back brace may slow curvature of the spine.
Medicines may include:
In severe cases, surgery may be needed to release muscles that are painfully tight. If there are heart problems, a pacemaker may be needed.
Muscular dystrophy is an inherited disease. Get genetic counseling if you are concerned about having a child with muscular dystrophy, especially if you:
Muscular Dystrophy Association
Muscular Dystrophy Family Foundation
Canadian Institutes of Health Research
Muscle Dystrophy Canada
Aartsma-Rus A, den Dunnen JT, van Ommen GJ. New insights in gene-derived therapy: the example of Duchenne muscular dystrophy. Ann NY Acad Sci. 2010;1214:199-212.
Amato AA, Griggs RC. Overview of the muscular dystrophies. Handb Clin Neurol. 2011;101:1-9.
Congenital muscular dystrophy. Muscular Dystrophy Association website. Available at: http://mda.org/search/site/congenital. Accessed October 7, 2013.
Distal muscular dystrophy. Muscular Dystrophy Association website. Available at: http://mda.org/disease/distal-muscular-dystrophy. Accessed October 7, 2013.
Duchenne muscular dystrophy. EBSCO DynaMed website. Available at: http://www.ebscohost.com/dynamed/what.php . Updated March 15, 2013. Accessed July 25, 2013.
Emery-dreifuss muscular dystrophy. Muscular Dystrophy Association website. Available at: http://mda.org/disease/emery-dreifuss-muscular-dystrophy. Accessed October 7, 2013.
Escolar DM, Hache LP, Clemens PR, et al. Randomized, blinded trial of weekend vs daily prednisone in Duchenne muscular dystrophy. Neurology. 2011;77(5):444-452.
Facioscapulohumeral muscular dystrophy. Muscular Dystrophy Association website. Available at: http://mda.org/disease/fsh-muscular-dystrophy. Accessed October 7, 2013.
Limb-girdle muscular dystrophy. Muscular Dystrophy Association website. Available at: http://mda.org/disease/limb-girdle-muscular-dystrophy. Accessed October 7, 2013.
NINDS muscular dystrophy information page. National Institute of Neurological Disorders and Stroke website. Available at: http://www.ninds.nih.gov/disorders/md/md.htm . Updated February 14, 2013. Accessed July 25, 2013.
Oculopharyngeal muscular dystrophy. Muscular Dystrophy Association website. Available at: http://mda.org/dis.... Accessed October 7, 2013.
Last reviewed June 2013 by John C. Keel, MD
Last Updated: 10/14/2013