Appointment Center (303) 436-4949



The pancreas is a long, flat, pear-shaped organ that sits behind the stomach. It makes enzymes that help to break down food for use by the body. The enzymes pass from the pancreas through a duct to the small intestine.

Acute pancreatitis is an inflammation of the pancreas that occurs suddenly, then passes after treatment.

The Pancreas

Copyright © Nucleus Medical Media, Inc.

Causes  ^

Pancreatitis may be caused by a number of conditions such as:

  • Blockage of the ducts from:
    • Gallstones
    • Cancer growth
    • Diseases of the small intestine
  • Alcohol
  • Surgery or trauma to the pancreas
  • Certain medications, such as those that treat cancer
  • Poor blood flow to the pancreas
  • Complications of endoscopic retrograde cholangiopancreatography (ERCP) —procedure to treat or diagnose problems of the pancreas

The enzymes are normally not active in the pancreas. Inflammation can turn on the enzymes in the pancreas which can damage the inside of the pancreas.

Risk Factors  ^

Factors that may increase the risk of having acute pancreatitis include:

  • Alcohol use disorder
  • Family history of pancreatitis
  • Personal history of previous acute pancreatitis
  • Congenital conditions, such as pancreas divisum
  • HIV or other viral infections, such as mumps or hepatitis B
  • Bacterial and parasitic infections
  • Hypertriglyceridemia—high blood triglyceride levels
  • Certain medications, such as those that treat high blood pressure
  • Pancreatic cancer
  • Hyperlipidemia—high blood fat levels
  • Hypercalcemia—elevated blood calcium levels
  • Cystic fibrosis
  • Scorpion or other venomous bite
  • Exposure to certain toxins because of work duties or environment

Symptoms  ^

Symptoms may start once or occur many separate times. A flare-ups of symptoms is known as an attack.

Symptoms may include:

  • Severe pain in the center of the upper abdomen:
    • Pain may spread into the upper back
    • Pain is often made worse by eating, walking, or lying down on your back
  • Nausea and vomiting
  • Low grade fever
  • Bloating
  • Yellowish color of the skin or whites of the eyes—jaundice
  • Rarely, shock—a medical emergency in which the organs and tissues do not receive adequate blood or fluids

Untreated acute pancreatitis may progress into chronic pancreatitis. This is a more serious condition that can lead to permanent damage of the pancreas.

Diagnosis  ^

You will be asked about your symptoms and medical history. A physical exam will be done. Your doctor may ask about your alcohol habits and what medications you take. Blood tests will help to make the diagnosis. Certain enzymes are much higher in the blood with acute pancreatitis.

The doctor may also need to take images of the pancreas. The images can show changes to the pancreas, gallstones, or duct blockages. Images may be taken with:

The doctor will use information from all of the tests to make a diagnosis.

Treatment  ^

Treatment will depend on the severity of the attack and what is causing it. For example, if medication is the cause, your doctor may simply change the medication or the dose.

In most cases, acute pancreatitis will pass in a few days with proper care. Most will have no lasting damage. Treatment includes:


The pancreas begins to work anytime food and drink is taken. To allow the pancreas to fully rest, you will not be allowed to eat or drink. Fluid and nutrition can be given by IV to support you during this time. Pancreatitis can also cause an imbalance in other enzymes and insulin. The medical team will give you medications to help manage these side effects until the pancreatitis has passed.

Severe pancreatitis may take a few weeks to fully heal. A special liquid may be needed to give you better nutrition during recovery. The fluid is passed through a tube that is inserted into your nose and passed down into your stomach.

If treatment is needed for the cause of your pancreatitis, it will be done while you are in the hospital.


Surgery may be needed:

  • For severe cases that do not respond well to rest
  • To treat underlying conditions

Surgical options include:

  • Percutaneous catheter drainage—thin tubes are inserted into the abdomen to drain fluid from the pancreas.
  • ERCP—To remove gallstones or open any collapsed ducts.
  • Cholecystectomy—To remove the gallbladder, especially if gallstones were the cause. Will also reduce your chance of getting acute pancreatitis again.
  • Necrosectomy—Removal of dying or dead pancreatic tissue.

Prevention  ^

To help reduce your chances of acute pancreatitis:

  • Limit intake of alcohol to a maximum of 2 drinks a day for men and 1 drink a day for women.
  • If you have high cholesterol, restrict your intake of fat and follow your doctor’s treatment plan.
  • Increase your vegetable consumption.
  • Increase your activity level to help lose excess weight. Aim for 30 minutes per day on most days of the week.
  • Make sure your vaccinations are up to date. This includes mumps, rubella hepatitis B, and chickenpox.
  • If you smoke, talk to your doctor about ways to quit. Smoking can irritate the pancreas.
  • Avoid fatty meals. High amounts of fat intake put extra stress on the pancreas.

National Institute of Diabetes and Digestive and Kidney Diseases

National Pancreas Foundation


Canadian Association of Gastroenterology

Health Canada


Acute pancreatitis. EBSCO DynaMed Plus website. Available at: Updated June 5, 2017. Accessed December 21, 2017.

Acute pancreatitis. Tulane University School of Medicine website. Available at: Accessed December 21, 2017.

Causes of acute pancreatitis. EBSCO DynaMed Plus website. Available at: Updated May 26, 2016. Accessed December 21, 2017.

Pancreatitis. National Institute of Diabetes and Digestive and Kidney Diseases website. Available at: Accessed December 21, 2017.

Prevention of acute pancreatitis. EBSCO DynaMed Plus website. Available at: Updated November 28, 2016. Accessed December 21, 2017.

4/7/2014 DynaMed Plus Systematic Literature Surveillance Baker ME, Nelson RC, et al. ACR Appropriateness Criteria for acute pancreatitis. Available at: Updated 2013.

8/28/2014 DynaMed Plus Systematic Literature Surveillance Johnson CD, Besselink MG, Carter R. Acute pancreatitis. BMJ. 2014;349:g4859.

Last reviewed December 2017 by EBSCO Medical Review Board Michael Woods, MD, FAAP  Last Updated: 3/7/2017

Original text