Thiamine (B1)
by
Skye Schulte, MS, MPH
FunctionThiamine helps to process carbohydrates, fats, and proteins. Specifically, it is needed to make adenosine triphosphate, or ATP, the body’s main energy-carrying molecule. Thiamin is also necessary for memory and other brain functions. Recommended Intake TOP
Thiamin Deficiency TOPThiamine deficiencies are rare in the United States because thiamine is added to refined grains. However, deficiencies do sometimes occur. Symptoms of thiamine deficiency include:
Thiamine deficiency was more common before thiamine was added to refined grains. This deficiency can lead to beriberi, a disease that affects the cardiovascular, gastrointestinal , and nervous system. Thiamin Toxicity TOPThere have been no adverse effects reported with taking too much dietary thiamine—the body excretes any excess amount that is consumed. In rare instances, coughing, hives, itching swelling, and breathing difficulties have occurred from thiamine injections given by doctors. Major Food Sources TOPThiamine is mostly found in whole-grain and enriched grain products like bread, pasta, rice, and fortified cereals. These foods are enriched with thiamine because the vitamin is often lost during the refining process. Pork, liver, and other organ meats are naturally high in thiamine. This table lists good food sources of thiamine.
Health Implications TOPBeriberiA severe thiamine deficiency, though rare in the US, can cause the disease beriberi. Beriberi can damage the heart and the nervous system. Symptoms include fatigue, diarrhea, weight loss, memory loss, and heart failure. This condition is still seen in people who abuse alcohol, in people whose ability to absorb thiamine is impaired, and in developing countries where foods are not fortified. Treating beriberi with vitamin B1 cures most cases, though severe deficiency can cause irreversible damage. Korsakoff’s SyndromeA deficiency of thiamine can cause Korsakoff’s Syndrome, which mainly affects short-term memory. Symptoms of Korsakoff’s syndrome include difficulty with walking and balance, paralysis of some of the eye muscles, confusion, and drowsiness. It is often caused by alcoholism and also occurs with forms of brain damage, such as tumors, head injuries, and strokes. Treatment of Korsakoff’s syndrome involves intravenous thiamine and oral thiamine supplements over many months. If alcoholism is the cause, that also needs to be treated. Congestive Heart FailureIn people with congestive heart failure (CHF), the heart's ability to pump weakens, and fluid begins to accumulate in the lungs and legs. Loop diuretics are often prescribed to treat CHF. However, these drugs can deplete the body of thiamine. Since thiamine is required for normal heart function, this can cause problems. Thiamine supplements may be prescribed in these cases. Conditions That May Increase the Need for ThiamineWhile thiamine deficiency in a healthy person is uncommon, there are conditions that can increase the need for thiamine, making a deficiency possible. If you have any of the following conditions, talk with your doctor about your thiamine needs: Tips for Increasing Your Thiamin Intake: TOPTo help increase your intake of thiamin, add some of these to your diet:
RESOURCES:American Dietetic Association http://www.eatright.org United States Department of Agriculture http://www.usda.gov/wps/portal/usdahome CANADIAN RESOURCES:Canadian Council on Food and Nutrition http://www.ccfn.ca Dietitians of Canada http://www.dietitians.ca/ References:
Jordan J, Patel M, Jordan F, eds.
Thiamine: Catalytic Mechanisms in Normal and Disease States.
New York, NY: Marcel Dekker; 2003.
Nutrition Fact Sheet: Thiamin (vitamin B1). Northwestern University website. Available at:
http://www.feinber...
. Accessed May 4, 2009.
Thiamin.
Alternative Med Rev.
2003;8:59.
Thiamin. Linus Pauling Institute website. Available at: http://lpi.oregonstate.edu/infocenter/vitamins/thiamin/. Accessed April 13, 2011. Thiamin—B1. The World's Healthiest Foods website. Available at: http://whfoods.org/genpage.php?tname=nutrient&dbid=100. Accessed April 13, 2011. Last reviewed April 2011 by Brian Randall, MD Last Updated: 4/13/2011 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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