| Drug Interactions:

Colchicine

Vitamin B12 - Supplementation Possibly Helpful

Although primarily used on a short-term basis to treat attacks of gout, colchicine is increasingly being prescribed for longer periods as a gout preventive. This practice may heighten the chance of developing the nutritional deficiency discussed here.

Vitamin B12

Supplementation Possibly Helpful

Colchicine can impair intestinal absorption of vitamin B ₁₂, so taking a B ₁₂ supplement during extended colchicine therapy may be warranted.¹ 

References [ + ]

1. Webb DI, Chodos RB, Mahar CQ, et al. Mechanism of vitamin B12 malabsorption in patients receiving colchicine. N Engl J Med 279: 845850, 1968.

Last reviewed July 2012 by EBSCO CAM Review Board
Last Updated: 7/25/2012

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