| Drug Interactions:

Hydralazine

Vitamin B6 - Supplementation Likely Helpful | Coenzyme Q10 (CoQ10) - Supplementation Possibly Helpful | Coleus forskohlii - Theoretical Interaction

Hydralazine causes dilation of the walls of blood vessels and is sometimes used to treat hypertension.

Vitamin B6

Supplementation Likely Helpful

Hydralazine is known to deplete the blood of vitamin B ₆. Taking B ₆ supplements may prevent or reverse side effects of the medication.^1,2 

Coenzyme Q10 (CoQ10)

Supplementation Possibly Helpful

There is some evidence that hydralazine might impair the body's ability to manufacture the substance coenzyme Q ₁₀ (CoQ ₁₀).³  This suggests (but definitely does not prove) that taking CoQ ₁₀ supplements may produce a beneficial effect.

Coleus forskohlii

Theoretical Interaction

The herb Coleus forskohlii relaxes blood vessels and might have unpredictable effects if combined with hydralazine.

References [ + ]

1. Shils M, et al. (eds.). Modern nutrition in health and disease, 9th ed. Baltimore: Williams and Wilkins, 1999: 1634.

2. Goodman L and Gilman A. The pharmacological basis of therapeutics, 9th ed. Hardman J, et al (eds.). New York: McGraw-Hill, 1996: 1562.

3. Kishi H, et al. Bioenergetics in clinical medicine. III. Inhibition of coenzyme Q ₁₀ -enzymes by clinically used anti-hypertensive drugs. Res Commun ChemPathol Pharmacol 12(3): 533–40, 1975.

Last reviewed July 2012 by EBSCO CAM Review Board
Last Updated: 7/25/2012

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