Metabolic syndrome is a group of risk factors. They raise a person’s chances of having heart disease, stroke, or type 2 diabetes. People who have this health problem have three or more of these risks: high blood pressure, high blood fat levels, high fasting blood glucose, and weighing too much.
Medicine and healthy habits can help a person who has metabolic syndrome. Natural therapies have also been used to lower cholesterol and blood pressure. They may also help with weight loss. They should not be used in place of standard care.
These herbs and supplements are likely to improve markers of metabolic syndrome:
These herbs and supplements may improve markers of metabolic syndrome:
Editorial process and description of evidence categories can be found at EBSCO NAT Editorial Process.
Talk to your doctor about any supplements or therapy you would like to use. Some may get in the way of treatment. They can also make illness worse or cause new problems. Examples include:
A1. Li Q, Li L, et al. [Effect of electroacupuncture in lipid metabolism in metabolic syndrome]. Zhongguo Zhen Jiu. 2010;30(9):713-716.
A2. Chen J, Xing H, et al. [Regulative effects of the acupuncture on glucose and lipid metabolism disorder in the patients of metabolic syndrome]. Xhongguo Zhen Jiu. 2017;37(4):361-365.
B. Herbs and Supplements
B1. Gurrola-Díaz CM, García-López PM, et al. Effects of Hibiscus sabdariffa extract powder and preventative treatment on the lipid profiles of patients with metabolic syndrome. Phytomed. 2010;17:500-505.
B2. Belcaro G, Cornelli U, et al. Pycnogenol® supplementation improves health risk factors in subjects with metabolic syndrome. Phytother Res. 2013;27(10):1572-1578.
B3. Díaz-Flores M, Cruz M, et al. Oral supplementation with glycine reduces oxidative stress in patients with metabolic syndrome, improving their systolic blood pressure. Can J Physiool Pharmacol. 2013;91(10):855-860.
B4. Qu X, Jin F, et al. Magnesium and the risk of cardiovascular events: a meta-analysis of prospective cohort studies. PLoS One. 2013;8(3):e57720.
B5. Ju SY, Choi WS, et al. Dietary magnesium intake and metabolic syndrome in the adult population: dose-response meta-analysis and meta-regression. Nutrients. 2014 Dec 22;6(12):6005-6019.
B6. Huang YM, Xu JH, et al. Efficacy of the wen dan decoction, a Chinese herbal formula, for metabolic syndrome. Altern Ther Health Med. 2015 Jul-Aug;21(4):54-67.
B7. Fang X, Wang K, et al. Dietary magnesium intake and the risk of cardiovascular disease, type 2 diabetes, and all-cause mortality: a dose-response meta-analysis of prospective cohort studies. BMC Med. 2016;14(1):210.
B8. Zhang XM, Zhang YB, et al. Soy Protein Supplementation Reduces Clinical Indices in Type 2 Diabetes and Metabolic Syndrome. Yonsei Med J. 2016 May;57(3):681-689.
B9. Gupta Jain S, Puri S, et al. Effect of oral cinnamon intervention on metabolic profile and body composition of Asian Indians with metabolic syndrome a randomized double-blind control trial. Lipids Health Dis. 2017;16(1):113.
B10. Tabrizi R, Akbari M, et al. The Effects of Selenium Supplementation on Glucose Metabolism and Lipid Profiles Among Patients with Metabolic Diseases: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Horn Metab Res. 2017;49(11):826-830.
B11. Akbari M, Tabrizi R, et al. The Effects of Folate Supplementation on Diabetes Biomarkers Among Patients with Metabolic Diseases: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Horm Metab Res. 2018;50(2):93-105.
B12. Li NY, Yu H, et al. Astragalus Membranaceus Improving Asymptomatic Left Ventricular Diastolic Dysfunction in Postmenopausal Hypertensive Women with Metabolic Syndrome: A Prospective, Open-Labeled, Randomized Controlled Trial. Chin Med J (Engl). 2018;131(5):516-526.
B13. Tabrizi R, Ostadmohammadi V, et al. The effects of inositol supplementation on lipid profiles among patients with metabolic diseases: a systematic review and meta-analysis of randomized controlled trials. Lipids Health Dis. 2018;17(1):123.
B14. Tabrizi R, Lankarani KB, et al. The effects of folate supplementation on lipid profiles among patients with metabolic diseases: A systematic review and meta-analysis of randomized controlled trials. Diabetes Metab Syndr. 2018;12(3):423-430.
B15. Nussbaumerova B, Rosolova H, et al. Chromium Supplementation Reduces Resting Heart Rate in Patients with Metabolic Syndrome and Impaired Glucose Tolerance. Biol Trace Elem Res. 2018;183(2):192-199.
B16. Ebrahimi-Mameghani M, Asghari-Jafarabadi M, et al. TCF7L2-rs7903146 polymorphism modulates the effect of artichoke leaf extract supplementation on insulin resistance in metabolic syndrome: a randomized, double-blind, placebo-controlled trial. J Integr Med. 2018;16(5):329-334.
B17. Akbari M, Ostadmohammadi V, et al. The effects of alpha-lipoic acid supplementation on glucose control and lipid profiles among patients with metabolic diseases: A systematic review and meta-analysis of randomized controlled trials. Metabolism. 2018;87:56-69.
B18. Doosti-Irani A, Ostadohammadi V, et al. The Effects of Melatonin Supplementation on Glycemic Control: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Horm Metab Res. 2018;50(11):783-790.
B19. Fogacci F, Grassi D, et al. Metabolic effects of berberine-silymarin association: A meta-analysis of randomized, double-blind, placebo-controlled clinical trials. Phytother Res. 2019;33(4):862-870.
B20. Azhdari M, Karandish M, et al. Metabolic benefits of curcumin supplementation in patients with metabolic syndrome: A systematic review and meta-analysis of randomized controlled trials. Phytother Res. 2019 May;33(5):1289-1301.
B21. Zhang XM, Zhang YB, et al. Soy Protein Supplementation Reduces Clinical Indices in Type 2 Diabetes and Metabolic Syndrome. Yonsei Med J. 2016;57(3):681-689.
B22. Simental-Mendía, Sahebkar A, et al. A systematic review and meta-analysis of randomized controlled trials on the effects of magnesium supplementation on insulin sensitivity and glucose control. Pharmacol Res. 2016;111:272-282.
C. Other Therapies
C1. Blanco Mejia S, Kendall CW, et al. Effect of tree nuts on metabolic syndrome criteria: a systematic review and meta-analysis of randomised controlled trials. BMJ Open. 2014 Jul 29;4(7):e004660.
C2. Amiot MJ, Riva C, et al. Effects of dietary polyphenols on metabolic syndrome features in humans: a systematic review. Obes Rev. 2016 Jul;17(7):573-86.
D1. Chu P, Gotnik RA, et al. Th effectiveness of yoga in modifying risk factors for cardiovascular disease and metabolic syndrome: A systematic review and meta-analysis of randomized trials. Eur J Prev Cardiol. 2016;23(3):291-307.
D2. Cramer H, Langhorst J, et al. Yoga for metabolic syndrome: A systematic review and meta-analysis. Eur J Prev Cardiol. 2016 Dec;23(18):1982-1993.
Last reviewed February 2020 by EBSCO NAT Review Board
Eric Hurwitz, DC
Last Updated: 5/26/2020