Reye syndrome is a serious, but rare condition. It causes a buildup of fat and swelling in most organs. It's most harmful to the liver and brain.
It tends to happen as you get better from a viral infection.
The cause of Reye syndrome is unknown. It's likely to be a combination of your genes and environment.
Reye syndrome is most common in children aged 2 to 16 years. But, it can happen at any age. Your chances of Reye syndrome are higher for:
Symptoms appear after a viral infection passes. They worsen as time passes.
Common ones are:
Later symptoms may progress to:
Call a doctor right away if you or your child has any of these. Especially after a viral infection.
You will be asked about your symptoms and health history. Your answers and a physical exam may point to Reye syndrome.
You may also have:
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The earlier Reye syndrome is treated, the faster you'll get better.
The goal is to protect the brain and other organs from damage. This can be done with:
These are used to:
Nutrients and fluids are given through an IV.
The brain, heart, and lungs will be carefully watched. This way, any further care can be started right away.
To help lower the chances of Reye syndrome:
Healthy Children—American Academy of Pediatrics
National Reye's Syndrome Foundation
About Kids Health—The Hospital for Sick Children
Reye syndrome. EBSCO DynaMed Plus website. Available at: http://www.dynamed.com/topics/dmp~AN~T114525/Reye-syndrome . Updated May 31, 2017. Accessed August 24, 2018.
Reye syndrome. Merck Manual Professional Version website. Available at: https://www.merckmanuals.com/professional/pediatrics/miscellaneous-disorders-in-infants-and-children/reye-syndrome. Updated February 2017. Accessed August 24, 2018.
Reye's syndrome information page. National Institute of Neurological Disorders and Stroke website. Available at: https://www.ninds.nih.gov/Disorders/All-Disorders/Reyes-Syndrome-Information-Page. Updated July 2, 2018. Accessed August 24, 2018.
What is Reye's syndrome? American Liver Foundation website. Available at: https://liverfoundation.org/for-patients/about-the-liver/diseases-of-the-liver/reye-syndrome. Accessed August 24, 2018.
What is Reye's syndrome? National Reyes Syndrome website. Available at:
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Accessed August 24, 2018.
Last reviewed May 2018 by
EBSCO Medical Review Board
Marcin Chwistek, MD
Last Updated: 8/24/2018