CRDAMC Homepage | CRDAMC Library Phone #: (254) 288-8366 | CRDAMC Library Fax #: (254) 288-8368

Search Health Library

Atypical Depression

(Depression with Atypical Features)


Depression is a mental illness marked by feelings of profound sadness and lack of interest in activities. It is a persistent low mood that interferes with the ability to function and appreciate things in life.

Atypical depression is depression with periods of mood brightening in response to positive events. Atypical depression will also have some symptoms that are not often found with depression.

Causes    TOP

The exact cause of atypical depression is not known but probably due to changes in brain chemistry. It is likely from a combination of genetic and environmental factors.

The Brain

Brain Man Face
Copyright © Nucleus Medical Media, Inc.

Risk Factors    TOP

While the exact cause of depression is not clearly established, there are several factors that are associated with atypical depression such as:

  • Having a family history of depression
  • Having a personal history of mental illness
  • Chronic illness, such as cancer
  • Stressful or traumatic life events
  • History of physical or sexual abuse
  • History of drug or alcohol use disorder
  • Certain medications
  • Lack of a support system

Symptoms    TOP

People with atypical depression have depression with periods of mood brightening, known as mood reactivity. Other symptoms that may occur include:

  • Overeating
  • Oversleeping
  • Heavy feeling in the arms or legs
  • Feeling rejected

Diagnosis    TOP

There is no blood test or diagnostic test for atypical depression. You will be asked about your symptoms and medical history. The doctor may also ask about depression symptoms and behaviors as well as any family history of mental health issues.

Specific mental health questionnaires may be done. This will help the doctor get detailed information about your speech, thoughts, memory, and mood. A physical exam and other tests can help rule out other causes.

Treatment    TOP

Combination treatment of medication and psychotherapy is often the most effective.

Antidepressant Medications

Antidepressant medications may be most effective in people with atypical depression. These medications can take 2-6 weeks to reach their maximum effectiveness. There are many different types of medications to treat atypical depression. You will work with your doctor to find the medication that benefits you the most and has the fewest side effects.


Psychotherapy for atypical depression consists of various types of counseling. These include cognitive behavior therapy (CBT), interpersonal therapy, psychodynamic therapy, or a combination of these. Therapy is designed to help you cope with difficulties in relationships, change negative thinking and behavior patterns, and resolve difficult feelings.

Exercise    TOP

A regular exercise program has been shown to relieve some of the symptoms. It should play a large role in the overall management of atypical depression.

Prevention    TOP

Whether or not depression develops is part of genetic makeup that cannot be prevented. However, certain habits may help decrease the risk of depressive episodes:

  • Being aware of your personal risk factors
  • Having a psychiatric evaluation and psychotherapy if needed
  • Developing social supports
  • Learning stress management techniques
  • Exercising regularly
  • Not abusing alcohol or drugs
  • Getting adequate sleep, rest, and recreation
  • Eating healthful foods, including fruits, vegetables, and whole grains


Depression and Bipolar Support Alliance


Canadian Mental Health Association
Canadian Psychiatric Association


Atypical depression. Mayo Clinic website. Available at:
...(Click grey area to select URL)
Accessed October 3, 2017.
Major depressive disorder (MDD). EBSCO DynaMed Plus website. Available at: https://www.dyname.... Updated July 19, 2017. Accessed October 3, 2017.
Quitkin F. Depression with atypical features: diagnostic validity, prevalence, and treatment. Primary Care Companion J Clin Psychiatry. 2002;4(3):94-99.
Singh T, Williams K. Atypical depression. Psychiatry (Edgmont). 2006;3(4):33-39.
Last reviewed September 2017 by EBSCO Medical Review Board Adrian Preda, MD
Last Updated: 03/07/2016

EBSCO Information Services is fully accredited by URAC. URAC is an independent, nonprofit health care accrediting organization dedicated to promoting health care quality through accreditation, certification and commendation.

This content is reviewed regularly and is updated when new and relevant evidence is made available. This information is neither intended nor implied to be a substitute for professional medical advice. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with questions regarding a medical condition.

To send comments or feedback to our Editorial Team regarding the content please email us at Our Health Library Support team will respond to your email request within 2 business days.

Health Library: Editorial Policy | Privacy Policy | Terms and Conditions | Support
36000 Darnall Loop Fort Hood, Texas 76544-4752 | Phone: (254) 288-8000