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(Hyaluronic Acid Injection; Injection, Hyaluronic Acid)


Viscosupplementation is an injection of a fluid called hyaluronic acid into a joint, most commonly the knee or shoulder.

Reasons for Procedure    TOP

This injection is used to treat the symptoms of osteoarthritis (OA).

Joints Affected by Osteoarthritis

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Healthy joints contain synovial fluid. This fluid lubricates and provides nutrients to the joints. With OA, the synovial fluid becomes thinner and less useful as a lubricant for the joint.

Hyaluronic acid, which is found in synovial fluid, is injected into the joint. This makes the synovial fluid act as a better lubricant. It is hoped that this will reduce pain and improve function of the joint. In some cases, getting this injection may help to postpone surgery on the joint.

Viscosupplementation may be a good option if you have tried other types of treatment and these have failed.

Possible Complications    TOP

Problems from the procedure are rare, but all procedures have some risk. Your doctor will review potential problems, like:

  • Pain and swelling
  • Infection at the injection site
  • Bleeding
  • Allergic reaction to the hyaluronic acid or local anesthetic product
  • Inflammation of the blood vessels—vasculitis
  • Gout

These factors reduce the chance that viscosupplementation will be effective for you:

  • Advanced OA
  • Age 65 years and older

What to Expect    TOP

Prior to Procedure

Before getting this injection, your doctor will most likely have you try many other ways to treat OA such as:

  • Pain medications
  • Corticosteroid injections
  • Physical therapy
  • Weight loss

If these methods are not helpful, then viscosupplementation may be a good option for you. Before the injection, your doctor may:

  • Have x-rays done to determine the severity of your OA
  • Ask you if you have any allergies to the ingredients in the hyaluronic acid product

If you are taking any prescription medications, over-the-counter products, or herbs and supplements, talk to your doctor. There could be an interaction with the injection.

Description of the Procedure

First, your doctor will clean the skin where the needle will be inserted. A local anesthetic may be applied to numb the area. If you have swelling in the affected joint, the doctor will use a needle to remove the excess fluid. Next, a needle will be used to inject the hyaluronic acid into the joint. If needed, both joints can be done at the same appointment.

While your schedule for receiving injections will vary depending on the brand. You may have just 1 injection or a series of 3 injections spread out over a period of days. You may need to go through injections more than once. In some cases, it can relieve pain for months to years.

How Long Will It Take?    TOP

The procedure usually takes a few minutes to do.

Will It Hurt?    TOP

You may feel the prick of the needle. Right after the injection, you may have some mild pain, warmth, and swelling around the affected joint.

Post-procedure Care    TOP

At Home

When you return home after the procedure:

  • Apply ice to the affected joint to reduce swellng and pain.
  • Avoid straining the affected joint for the first couple of days. Do not stand for a long time or do strenuous activity, like heavy lifting.

As you go through the injection cycles, you may have:

  • Less pain
  • Improved mobility

Call Your Doctor    TOP

Call your doctor if any of these occur:

  • Signs of infection, including fever and chills
  • Redness, swelling, increasing pain, bleeding, or discharge from the injection site
  • Signs of allergic reaction
  • Increased pain or swelling in the affected joint

If you think you have an emergency, call for emergency medical services right away.


American Chronic Pain Association
Ortho Info—American Academy of Orthopaedic Surgeons


Arthritis Society


Arnold W, Fullerton D, Holder S, May CS. Viscosupplementation: managed care issues for osteoarthritis of the knee. J Managed Care Pharm. 2007;13(4 Suppl):S3-S19. Available at:
...(Click grey area to select URL)
Injection therapy for osteoarthritis (OA) of the knee. EBSCO DynaMed Plus website. Available at: http://www.dynamed.... Updated December 15, 2017. Accessed December 20, 2017.
Joint aspiration. Cleveland Clinic website. Available at: Accessed December 20, 2017.
Osteoarthritis (OA) of the glenohumeral joint. EBSCO DynaMed Plus website. Available at: http://www.dynamed.... Updated December 6, 2017. Accessed December 20, 2017.
Viscosupplementation treatment for arthritis. Ortho Info—American Academy of Orthopaedic Surgeons website. Available at: Updated June 2015. Accessed December 20, 2017.
Last reviewed December 2017 by EBSCO Medical Review Board Michael Woods, MD, FAAP
Last Updated: 12/20/2017

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