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Acute Kidney Injury
(AKI; Acute Kidney Failure; Acute Renal Failure; Acute Renal Insufficiency)
by Madeline Vann, MPH
Acute kidney injury (AKI) is the sudden loss of kidney function. Kidneys clean waste from the blood and manage the balance of fluid in the body.
There are many possible causes of sudden kidney failure because there are 3 anatomical sites for problems to occur in the renal system: before the blood enters the kidneys, within the kidneys, and after the urine is processed by the kidneys and enters the ureters.
AKI can result from problems with blood flow to the kidney, which can be caused by acute renal artery obstruction, blood loss, or dehydration. It can also result from conditions such as infections that interfere with the work of the kidney.
The most common cause of AKI occurs inside the kidney. Acute tubular necrosis is the death of the cells inside the kidney that act as the blood's filter. These cells die when they are deprived of oxygen. This can be due to surgical complications, inflammatory processes, blood clots, or the side effects of certain medications. Physical problems, such as swollen prostate glands or kidney stones can also cause AKI.
Risk Factors TOP
Factors that may increase your chance of AKI include:
Most people do not have symptoms. In those that have them, AKI may cause:
You will be referred to a kidney specialist (nephrologist) for diagnosis and treatment. You will be asked about your symptoms and medical history, including any medications you are taking. A physical exam will be done.
Your bodily fluids may be tested. This can be done with:
Imaging tests evaluate the kidney and surrounding structures. These may include:
Treatment for AKI will depend on the exact cause and severity. Your doctor may advise:
To help reduce your chance of AKI:
National Institute of Diabetes and Digestive and Kidney Diseases
National Kidney Foundation
Kidney Foundation of Canada
Hilton R. Acute renal failure. BMJ. 2006;333(7572):786-790.
Needham E. Management of acute renal failure. Am Fam Physician. 2005;72(9):1739-1746. Accessed July 13, 2013.
Rondon-Berrios H, Palevsky PM. Treatment of acute kidney injury: An update on the management of renal replacement therapy. Curr Opin Nephrol Hypertens. 2007;16(2):64-70.
Venkataraman R, Kellum JA. Prevention of acute renal failure. Chest. 2007;131(1):300-308.
Last reviewed June 2016 by Adrienne Carmack, MD
Last Updated: 5/11/2013
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