Allergic bronchopulmonary aspergillosis (ABPA) is an allergic lung disorder. It is related to a fungus. Aspergillosis can also occur as:
ABPA is caused by an allergic reaction to an inhaled fungus. It grows and flourishes in decaying vegetation, soil, certain foods, dust, and water. The inhaled fungus colonizes mucus in the lungs, causing:
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Factors that may increase your chances of ABPA:
Symptoms of ABPA are usually those of progressive asthma. These include:
As ABPA progresses, other symptoms may occur:
You will be asked about your symptoms and medical history. A physical exam will be done.
Images may be taken of your bodily structures. This can be done with:
Your bodily fluids and tissues may be tested. This can be done with:
Your lungs may be tested. This can be done with pulmonary function tests (PFTs).
ABPA can appear quite similar to non-ABPA induced asthma. ABPA is typically diagnosed after several repeat tests for ABPA are positive over a number of months or years.
The goals of treatment include:
ABPA is usually treated with:
Avoiding exposure to fungus is the best way to prevent ABPA. However, this is difficult because fungus is so prevalent in the environment. Guidelines to help prevent exposure to the fungus include:
Measures to avoid symptoms and prevent permanent lung damage caused by ABPA include:
American Lung Association
Centers for Disease Control and Prevention
Allergic bronchopulmonary aspergillosis. EBSCO DynaMed Plus website. Available at:http://www.dynamed.com/topics/dmp~AN~T115466/Allergic-bronchopulmonary-aspergillosis. Updated January 6, 2017. Accessed December 11, 2017.
Allergic bronchopulmonary aspergillosis (ABPA). American Academy of Allergy Asthma & Immunology website. Available at: http://www.aaaai.org/conditions-and-treatments/related-conditions/allergic-bronchopulmonary-aspergillosis. Accessed December 11, 2017.
Wark PA, Gibson PG, Wilson AJ. Azoles for allergic bronchopulmonary aspergillosis associated with asthma. Cochrane Database Syst Rev 2004;(3): CD001108.
Last reviewed December 2017 by EBSCO Medical Review Board David L. Horn, MD, FACP Last Updated: 12/20/2014