Tardive dyskinesia (TD) is a movement disorder. It results from using medicines used to treat psychiatric problems, like schizophrenia.
TD causes repeating movements you can’t control. They may affect the face, limbs, or trunk.
TD is caused by chronic use of certain antipsychotic medicines.
It is not known why TD happens. Not all people who take these drugs get TD.
TD is more common in women. It is also more common in older adults. Other things that may raise your risk are:
Movements may be once and a while or all of the time. They may or may not be noticed by others. Symptoms may start while on the medicine or within weeks of stopping it.
You may have:
The doctor will ask about your symptoms and health history. A physical exam will be done. There is no specific test for TD. It is suspected if you are taking these medicines and have movements you can’t control.
Tests to rule out other disorders may include:
Copyright © Nucleus Medical Media, Inc.
To treat TD, your doctor may:
Symptoms may get better over time even if you keep taking the medicine. Younger people tend to do better.
Some medicines may help lower symptoms, such as:
Deep Brain Stimulation (DBS) may be used on people who do not respond to medicine.
To help reduce your chances of TD from an antipsychotic drug:
National Alliance on Mental Illness
National Institute of Neurological Disorders and Stroke
Canadian Mental Health Association
Mental Health Canada
Bai YM, Yu SC, Linn CC. Risperidone for severe tardive dyskinesia: A 12-week randomized, double-blind, placebo-controlled study. J Clin Psychiatry. 2003;64(11):1342-1348.
Damier P. Drug-induced dyskinesias. Curr Opin Neurol. 2009;22(4):394-399.
Kinon BJ, Jeste DV, Kollack-Walker S, Stauffer V, Liu-Seifert H. Olanzapine treatment for tardive dyskinesia in schizophrenia patients: a prospective clinical trial with patients randomized to blinded dose reduction periods. Prog Neuropsychopharmacol Biol Psychiatry. 2004;28(6):985-996.
McGrath JJ, Soares KV. Neuroleptic reduction and/or cessation and neuroleptics as specific treatments for tardive dyskinesia. Cochrane Database Syst Rev. 2006;(1):CD000459.
Meco G, Fabrizio E, Epifanio A. Levetiracetam in tardive dyskinesia. Clin Neuropharmacol. 2006;29(5):265-268.
Pham DQ, Plakogiannis R. Vitamin E supplementation in Alzheimer’s disease, Parkinson’s disease, tardive dyskinesia, and cataract: Part 2. Ann Pharmacother. 2005;39(12):2065-2072.
Sachdev PS. The current status of tardive dyskinesia. Australian and New Zealand Journal of Psychiatry. 2000;34(3):355-369.
Soares KV, McGrath JJ. The treatment of tardive dyskinesia: A systematic review and meta-analysis. Izophr Res. 1999;39(1):1-16.
Tardive dyskinesia. EBSCO DynaMed Plus website. Available at:http://www.dynamed.com/topics/dmp~AN~T113751/Tardive-dyskinesia. Updated May 31, 2018. Accessed June 13, 2018.
Thema B, Srivastava V, Tiwari AK. Genetic underpinnings of tardive dyskinesias: passing the baton to pharmacogenetics. Pharmacogenomics. 2008;9(9):1285-1306.
Last reviewed June 2018 by EBSCO Medical Review Board Rimas Lukas, MD Last Updated: 6/13/2018