Isoflavones are naturally occurring, hormonally active substances found in soy and other foods. Chemical modifications of isoflavones have been studied as possible alternative treatments for various conditions. One of these, ipriflavone, was developed primarily for treating osteoporosis. Methoxyisoflavone is a chemical derivative of ipriflavone, but it is marketed as a bodybuilding aid.
Methoxyisoflavone is not a nutrient and is not supplied to any meaningful extent in food. However, it is possible that, once in the body, natural isoflavones, such as daidzein, may be converted to some extent into methoxyisoflavone.
A typical recommended dose of methoxyisoflavone is 200 mg to 400 mg taken twice daily.
Methoxyisoflavone is marketed as an anabolic steroid, said to increase muscle mass without causing androgenic (testosterone-like) effects. However, there is no meaningful evidence that it actually works.
The use of methoxyisoflavone in the US began with two US patents established in the late 1970s.1,2 The patent applications report a few research studies performed by the Hungarian pharmaceutical company Chinoin. None of these studies were published in peer-reviewed journals; furthermore, even as described, this research is altogether inadequate to demonstrate effectiveness, consisting as it did only of animal studies and exceedingly preliminary studies on humans. Proof of effectiveness is not required to establish a patent.
One placebo-controlled human trial on methoxyisoflavone was published in abstract form in 2001.3 Apparently, this study found that athletes who took 800 mg per day of methoxyisoflavone for 8 weeks experienced a significantly greater increase in muscle mass than those who took placebo. However, despite claims made by methoxyisoflavone retailers, this study was not published in a prestigious journal. Rather, it appeared in what is a called a “supplement” published in association with a fairly prestigious journal. Supplements are special editions printed by a journal for extra income; they explicitly lack the supervision, approval, review or imprimatur of the journal itself. For this reason, all studies published in journal supplements must be taken with a grain of salt. This is particularly so in cases like this, where only an abstract of the study was published rather than the full text of the study itself.
Another oft-repeated claim regarding methoxyisoflavone is that it is widely utilized in the livestock industry to enhance lean mass. However, if livestock breeders are in fact using methoxyisoflavone, they are keeping it quiet: an Internet search for “methoxyflavone” and “livestock” turned up numerous sites that sell supplements to humans (and make this claim to support the sales of their product), but not a single site by or for livestock breeders.
The bottom line: There is no meaningful evidence to indicate that methoxyisoflavone is useful as a sports supplement.
Methoxyflavone has not undergone comprehensive safety testing. Those who take it do so at their own risk.
1. Feuer L, Logrady N, Gottsegen A, et al. Anabolic-weight-gain promoting compositions containing isoflavone derivatives and method using same. United States Patent 3,949,085. April 6, 1976.
2. Feuer L, Farkas L, Nogradi M, et al. Metabolic 5-methyl-isoflavone-derivatives, process for the preparation thereof and compositions continuing the same. United States Patent 4,163,746. August 7, 1979.
3. Incledon T, Gammeren DV, Antonio JA. The effects of 5-methylisoflavone on body composition and performance in college aged men. Med Sci Sports Exer. 2001;33(5 suppl):S338 [abstract].
Last reviewed December 2015 by EBSCO CAM Review Board Last Updated: 12/15/2015