Carl R. Darnall Army Medical Center - Health Library

Arrhenoblastoma

(Androblastoma; Sertoli-Leydig Cell Tumor of the Ovary)

Definition

An arrhenoblastoma is a rare type of ovarian tumor. This tumor primarily secretes the male sex hormone, testosterone, and rarely the female sex hormone, estrogen.

Arrhenoblastomas are generally benign, meaning they do not normally spread beyond the ovary.

Arrhenoblastoma
Ovarian Cancer

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Causes ^

The cause of arrhenoblastoma is unknown.

Risk Factors ^

Arrhenoblastomas are most common in young women between the ages of 20 and 30 years of age. However, they can occur at any age, including in toddlers, young girls, and postmenopausal women.

Arrhenoblastoma may also be a rare complication of pregnancy.

Symptoms ^

In many cases, infrequent menstrual periods or cessation of menstrual periods is the only symptom.

In up to 1 in 3 patients, arrhenoblastoma is accompanied by masculinization, including any of the following:

Diagnosis ^

You will be asked about your symptoms and medical history. A physical exam will be done.

Your bodily fluids may be tested. This can be done with blood tests to check hormone levels.

Images may be taken of your bodily structures. This can be done with ultrasound.

Pelvic Ultrasound
Pelvic Ultrasound

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Treatment ^

Treatment involves surgery to remove one or both ovaries. This procedure is usually successful in returning normal menstruation (in premenopausal women) and ceasing masculinization. If the tumor is late stage and particularly aggressive (which is rare), radiation therapy, chemotherapy, or both, in addition to surgery, may be needed.

Prevention ^

There are no known ways to prevent ovarian cancer of any kind, as the cause is unknown.

RESOURCES:

The Endocrine Society
http://www.endo-society.org

Ovarian Cancer Research Fund Alliance
https://ocrfa.org

CANADIAN RESOURCES:

Canadian Cancer Society
https://www.cancer.ca

Ovarian Cancer Canada
http://www.ovariancanada.org

REFERENCES:

Choong S, Fuller P, et al. Sertoli-Leydig cell tumor of the ovary, a rare cause of precocious puberty in a 12-month-old infant. J Clin Endocrinol Metab. 2002;87:49-56.

Colombo N, Parma G, et al. Management of ovarian stromal cell tumors. J Clin Oncol. 2007;20:2944-2951.

McCluggage WG, McKenna M, et al. CD56 is a sensitive and diagnostically useful immunohistochemical marker of ovarian sex cord stromal tumor. Int J Gyn Pathol. 2007;26:322-327.

Sachdeva P, Arora R, et al. Cell tumor: a rare ovarian neoplasm. Gynecologic Endocrinology. 2008;24(4):230-234.

Sex cord-stromal tumors. Johns Hopkins Pathology website. Available at: http://ovariancancer.jhmi.edu/stromal.cfm. Updated June 25, 2001. Accessed December 7, 2017.

Last reviewed December 2017 by Beverly Siegal, MD, FACOG  Last Updated: 12/20/2014