Carl R. Darnall Army Medical Center - Health Library

Acute Interstitial Nephritis

Definition

Acute interstitial nephritis (AIN) is a problem with your kidneys. The kidneys are unable to filter wastes from your blood effectively.

Anatomy of the Kidney
Glomerulonephritis

Copyright © Nucleus Medical Media, Inc.

Causes  ^

AIN has several causes:

Risk Factors  ^

AIN is more common in older adults. Your chances are also higher if you:

  • Take certain medicines
  • Have an infection

Symptoms  ^

AIN may cause:

  • Lower amounts of urine than normal
  • A general feeling of illness—malaise
  • Lack of hunger
  • Nausea and vomiting
  • Pain in your side
  • Joint aches
  • Low fever
  • Rash
  • Blood in your urine (rare)

Diagnosis  ^

The doctor will ask about your symptoms and health history. A physical exam and urine tests may point to AIN. You may also have:

  • Blood tests—to count blood cells and look for certain proteins that show how the kidneys are working
  • Kidney biopsy—confirms diagnosis, but not always needed
  • Ultrasound

Treatment  ^

AIN care depends on the cause. For example, if medicine you take is harming your kidneys, your doctor will make changes. Care also helps other symptoms such as a rash or fever. AIN care may also involve:

  • Antibiotics for bacterial infection
  • Corticosteroids to reduce inflammation
  • Dialysis—a machine works for your kidneys by filtering your blood

Prevention  ^

To help lower your chances of AIN, don’t take medicines you know cause kidney problems. Your doctor will find other medicines to help you.

RESOURCES:

National Institute of Diabetes and Digestive and Kidney Diseases
https://www.niddk.nih.gov

National Kidney Foundation
https://www.kidney.org

CANADIAN RESOURCES:

Health Canada
https://www.canada.ca

The Kidney Foundation of Canada
https://www.kidney.ca

REFERENCES:

Acute interstitial nephritis. EBSCO DynaMed website. Available at:http://www.dynamed.com/topics/dmp~AN~T115064/Acute-interstitial-nephritis. Updated December 9, 2014. Accessed May 30, 2018.

Kodner CM, Kudrimoti A. Diagnosis and management of acute interstitial nephritis. Am Fam Physician. 2003;67(12):2527-2534.

Plakoglannis R, Nogid A. Acute interstitial nephritis associated with coadministration of vancomycin and ceftriaxone: Case series and review of the literature. Pharmacotherapy. 2007:27(10):1456-1461.

Sierra F, Suzrez M, Rey M, Vela MF. Systematic review: Proton pump inhibitor-associated acute interstitial nephritis. Aliment Pharmaco Ther. 2007:26:545-553.

Tubulointerstitial nephritis. Merck Manual Professional Version website. Available at: https://www.merckmanuals.com/professional/genitourinary-disorders/tubulointerstitial-diseases/tubulointerstitial-nephritis. Updated July 2017. Accessed May 30, 2018.

Last reviewed May 2018 by EBSCO Medical Review Board Adrienne Carmack, MD  Last Updated: 5/30/2018