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(Agranulocytosis; Granulocytopenia; Granulopenia)
by Diana Kohnle
Neutropenia is the bone marrow’s inability to produce enough neutrophils, a type of white blood cell that helps to fight infections.
Neutropenia may be:
Neutropenia can be caused by destruction or using up white blood cells and/or by the failure of bone marrow to make enough white blood cells.
With congenital neutropenia, these problems are caused by a genetic defect.
With acquired neutropenia, these problems may be caused by:
Risk Factors TOP
Factors that increase your chance of developing neutropenia include:
Neutropenia does not result in symptoms. However, it can result in infection, which may have the following symptoms:
You will be asked about your symptoms and medical history. You will be asked about recent infections, medical treatments, and medications. A physical exam will be done.
Your bodily fluids and tissues may be tested. This can be done with:
Treatment will be based on the cause and severity of your neutropenia. Options include the following:
Medication for Infections Treatment
Antiviral, antibiotic, and antifungal medication may be needed to:
White Blood Cell-stimulating Factors
Granulocyte colony-stimulating factor (G-CSF) or granulocyte-macrophage colony-stimulating factor (GM-CSF) encourages the body to make more white blood cells.
Removal of Causative Agent TOP
When possible, the toxin or drug that is causing the problems will be removed.
You will be monitored if you are taking medication or having medical treatment that could lead to neutropenia. You may be given white blood cell stimulating medications before having treatments. This may prevent neutropenia.
Mouth Healthy—American Dental Association
National Organization for Rare Disorders, Inc.
The College of Family Physicians of Canada
Boulton F, Cooper C, et al. Neutropenia and agranulocytosis in England and Wales: incidence and risk factors. American Journal of Hepatology. 2003 Apr;72(4):248-54.
Neutropenia. EBSCO DynaMed Plus website. Available at: http://www.dynamed.com/topics/dmp~AN~T116576/Neutropenia. Updated March 19, 2015. Accessed September 27, 2016.
Last reviewed June 2016 by Michael Fucci, DO, FACC
Last Updated: 5/11/2013
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