Definition

Blood poisoning is an illness due to an infection or its toxin spreading through the bloodstream. The presence of bacteria in the blood is called bacteremia.

Short bursts of low levels of bacteria in the blood usually do not cause problems. However, if bacteria levels do not decrease sepsis may occur. This is a serious condition which can lead to death.

Causes

Sepsis occurs when large numbers of infectious agents exist in the blood. Infections with fungi and parasites may lead to sepsis as well. The initial infection often comes from:

• A burn, ulcer, or other open wound
• Pneumonia
• A urinary tract infection

Blood Flow Near Burn Wound Copyright © Nucleus Medical Media, Inc.

Bacteria can also enter the bloodstream directly from an outside source. A dirty needle used by an IV drug user can cause this type of infection. In some cases, the source of the infection is unknown.

Small amounts of bacteria enter into the blood with dental work or when brushing your teeth. Your body's immune system should fight off these bacteria.

Risk Factors    TOP

Factors that increase your chance of getting sepsis include:

• Recent illness or hospital care
• Frail health due to increased age
• Poorly working immune system due to:
  • Cancer or chemotherapy to treat cancer
  • Diabetes
  • AIDS or another immunosuppressive condition, such as an autoimmune disease or an immune deficiency
  • Immunosuppressive medications needed after a transplant
• Medical treatment with an invasive device
• IV drug abuse

Symptoms    TOP

The first symptoms depend on the site of the infection.

As the condition progresses to sepsis, symptoms include:

• Fever and chills
• Low temperature
• Paleness of skin color
• Listlessness
• Changes in mental status
• Rapid breathing
• Increased heart rate
• Decreased urine
• Low blood pressure
• Shock
• Problems with bleeding or clotting

Diagnosis    TOP

The doctor will ask about your symptoms and medical history and perform a physical exam. If sepsis is suspected, the doctor will try to find the source of the infection.

Tests include:

• Several blood cultures to confirm the diagnosis of sepsis
• Urine and other blood tests to check for signs of infection
• Cultures of urine, sputum, stool, and other secretions to check for bacteria or other infectious agents
• X-rays—a test that uses radiation to take a picture of structures inside the body
• CT scan—a type of x-ray that uses a computer to make pictures of structures inside the body
• MRI scan—a test that uses magnetic waves to make pictures of structures inside the body
• Other specialized tests depending on the source of the infection

Treatment    TOP

This condition will need to be treated aggressively. Treatment is aimed at the cause of the initial infection.

Early treatment improves the chance of survival. Life-saving steps may be needed to assist breathing and heart function. Patients usually need to be observed in an intensive care unit.

Prevention    TOP

It is not always possible to prevent blood poisoning. Avoiding IV drug abuse decreases your chance of sepsis. Healthcare professionals must also take steps to stop the spread of these infections. Getting prompt medical care for infections can reduce your risk of sepsis.