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(Renal Cell Carcinoma)
by Rick Alan
Kidney cancer is a disease in which cancer cells grow in the kidneys. The kidneys are 2 bean-shaped organs. They are located just above the waist, on each side of the spine. Their main function is to filter the blood and produce urine.
There are 2 main types of kidney cancer: Wilms tumor, which occurs mainly in children, and renal cell carcinoma in adults. The cells that line the ureter may also give rise to transitional cell cancer, and the connective tissues of the kidney may produce sarcomas, which are rare.
Cancer occurs when cells in the body divide without control or order. Normally, cells divide in a regulated manner. If cells keep dividing uncontrollably when new cells are not needed, a mass of tissue forms, called a growth or tumor. The term cancer refers to malignant growths. These growths can invade nearby tissues. Cancer that has invaded nearby tissues can then spread to other parts of the body.
It is not clear exactly what causes these problems in the cells, but it is probably a combination of genetics and environment.
Risk Factors TOP
Kidney cancer is more common in men, and in people over 50 years old. Other factors that may increase your chances of kidney cancer:
Kidney cancer may cause:
Your doctor will ask about your symptoms and medical history. A physical exam will be done.
Your bodily fluids and tissues may be tested. This can be done with:
Other tests evaluate the kidneys and other structures. These may include:
The physical exam combined with all of your test results, will help to determine the stage of cancer you have. Staging is used to guide your treatment plan. Like other cancers, kidney cancer is staged from I-IV. Stage I is a very localized cancer, while stage IV indicates a spread to other parts of the body.
Cancer treatment varies depending on the stage and type of cancer. Surgery is the most important component of any approach to cure kidney cancer. There is some information suggesting immunotherapies may be of some benefit. Radiation therapy can be used to treat kidney cancer that has spread to the lung, bones, or brain, but it is not a cure. Chemotherapy is not a very effective form of treatment.
Surgery involves the removal of a cancerous tumor, nearby tissue, and possibly nearby lymph nodes. Surgeries to treat kidney cancer include:
This is the use of radiation to kill cancer cells and shrink tumors. External radiation therapy is directed at the tumor from a source outside the body.
Chemotherapy is the use of drugs to kill cancer cells. Chemotherapy may be given in many forms including pill, injection, and through a tube called a catheter. The drugs enter the bloodstream and travel through the body destroying mostly cancer cells but also some healthy cells.
This procedure involves the use of drugs like interleukin-2 and interferon alpha to help the immune system fight and destroy cancer cells.
Targeted Therapy TOP
Targeted therapy includes using medications called tyrosine kinase inhibitors. These medications have been shown to increase the survival rate in people with kidney cancer. Another class of drugs called mammalian target of rapamycin (mTOR) inhibitors may also help people with kidney cancer live longer.
These medications may be prescribed to adults with advanced kidney cancer:
Measures to prevent kidney cancer are limited. In general:
American Cancer Society
Kidney Cancer Association
Canadian Cancer Society
The Kidney Foundation of Canada
General information about renal cancer. National Cancer Institute website. Available at: https://www.cancer.gov/types/kidney/patient/kidney-treatment-pdq. Updated December 31, 2016. Accessed October 9, 2017.
Kidney cancer. American Cancer Society website. Available at: https://www.cancer.org/cancer/kidney-cancer.html. Accessed October 9, 2017.
Renal cell carcinoma. EBSCO DynaMed Plus website. Available at: http://www.dynamed.... Updated May 31, 2017. Accessed October 9, 2017.
Renal cell carcinoma. Merck Manual Professional version website. Available at:
...(Click grey area to select URL)
Updated November 2013. Accessed October 9, 2017.
10/1/2014 DynaMed Plus Systematic Literature Surveillance. http://www.dynamed...: Bhaskaran K, Douglas I, Forbes H, et al. Body-mass index and risk of 22 specific cancers: a population-based cohort study of 5.24 million UK adults. Lancet. 2014;384(9945):755-765.
Last reviewed September 2017 by EBSCO Medical Review Board Mohei Abouzied, MD, FACP
Last Updated: 10/1/2014
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