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(Cutaneous Melanoma; Malignant Melanoma)


Melanoma is a type of skin cancer. It is the least common form of skin cancer, but it can be more serious because it is more likely to spread to other parts of the body.

Melanoma arises from the type of cell called melanocytes that give moles their dark colors. These cells can be found in the skin, eyes, digestive system, nail beds, or lymph nodes. Although melanoma is most common in the skin, it may also arise in these other areas.

Treatment for melanoma depends on how early it is detected, or if the melanoma has spread.


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Causes    TOP

Cancer occurs when cells in the body divide without control or order. Eventually these uncontrolled cells form a growth or tumor. The term cancer refers to malignant growths. These growths invade nearby tissues and spread to other parts of the body. It is not clear exactly what causes these problems in the cells but is probably a combination of genetics and environment.

Risk Factors    TOP

The most common risk factor for melanoma is exposure to ultraviolet radiation. The most common source of this radiation comes form the sun, but it is also found in sun lamps and tanning booths.

Melanoma is found most often in older adults, but it can happen in young adults. It is more common in people who are Caucasian. Other factors that may increase your chances of melanoma include:

  • Certain types of moles called dysplastic nevi, or atypical moles
  • Large nevi present at birth
  • Fair skin, freckling
  • Red or blonde hair
  • Light-colored eyes
  • Family members with melanoma
  • Excessive skin exposure to the sun without protective clothing or sunscreen
  • Certain occupations, such as telephone repair employees, harbor masters, and electrical fitters
  • Suppressed immune system

Symptoms    TOP

Melanomas are not usually painful. They often have no symptoms at first.

The first sign is often a change in the size, shape, color, or feel of an existing mole. Melanoma may also appear as a new, dark, discolored, or abnormal mole. Remember that most people have moles. Almost all moles are benign.

The following are signs that a mole may be a melanoma (ABCDE criteria):

  • A ssymetry or uneven shape—one half does not match the shape of the other half
  • B order or edges that are uneven—ragged, notched, blurred, or irregular; pigment may spread into surrounding skin
  • C olor variation or uneven color—color is uneven with shades of black, brown, or tan, and possibly even white, gray, pink, red, or blue
  • D iameter or size—usually larger than the eraser of a pencil (6 millimeters or ¼ inch)
  • E volution or change—usually growing larger, changing shape, changing color, or changing texture

Sign of Potential Melanoma

Skin Cancer Sign: Irregular Border on Mole
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Diagnosis    TOP

Your doctor will ask about your symptoms and medical history. A physical exam will be done. Your doctor will look at your skin and moles. You may be referred to an eye specialist if melanoma of the eye is suspected. A skin biopsy of the suspicious area will be done. The tissue will be examined under a microscope.

Your doctor may also examine lymph nodes. Enlarged lymph nodes may suggest the spread of melanoma. A sample of lymph node tissue may also be removed for testing.

Once melanoma is found, more tests will be done to determine the stage of cancer. Melanoma is staged like other cancers, from I to IV. The stage will help determine your treatment course.

Treatment    TOP

Treatment will depend on the location and stage of the melanoma. Talk to your doctor about the best treatment plan for you. Treatment options may include one or more of the following:


The melanoma and some healthy tissue around it will be removed. If a large area of tissue is removed, skin from another area of your body will be needed to cover the wound. Lymph nodes near the tumor may also be removed for testing or to stop the spread of cancer.


Chemotherapy is medication that kills cancer cells. It is used to treat advanced melanoma. There are many options and your doctor will choose the best ones for you.

Other Medications    TOP

Immunotherapy is used to treat advanced melanoma, and melanoma that has a high risk of return. Immunotherapy stimulates the body's own immune system to find and destroy cancer cells.

Some people have a genetic mutation in the BRAF gene that can cause the melanoma to grow and divide quickly. This BRAF mutation occurs in nearly half of all melanomas. Certain medications can help your body target cells with the BRAF mutation.

Radiation Therapy    TOP

Radiation therapy is the use of radiation to kill cancer cells and shrink tumors. It is usually used in combination with other therapies, but may be used alone for eye melanomas.

Prevention    TOP

To help reduce your chances of melanoma:

Early diagnosis and treatment is important. Take the following steps to find melanoma in its early stages:

  • See your doctor if you think you have notice any changes in any moles on your skin.
  • If you have many moles or a family history of melanoma, have your skin checked regularly for changes in moles.
  • Ask your doctor to show you how to do a skin self-exam. Do self-exams to look for any new or changing moles.


American Academy of Dermatology
Skin Cancer Foundation


Canadian Cancer Society
Canadian Dermatology Association


General information about melanoma. National Cancer Institute website. Available at: Updated August 25, 2017. Accessed October 9, 2017.
Melanoma. EBSCO DynaMed Plus website. Available at: Updated June 27, 2017. Accessed October 9, 2017.
Melanoma skin cancer. American Cancer Society website. Available at: Accessed October 9, 2017.
Physician quality reporting system quality measures. EBSCO DynaMed Plus website. Available at: http://www.dynamed.... Updated August 19, 2014. Accessed October 9, 2017.
5/18/2015 DynaMed Plus Systematic Literature Surveillance Perez-Gomez B, Pollán M, Gustavsson P, et al. Cutaneous melanoma: hints from occupational risks by anatomic site in Swedish men. Occup Environ Med. 2004;61(2):117-126.
Last reviewed September 2017 by EBSCO Medical Review Board Mohei Abouzied, MD, FACP
Last Updated: 8/5/2015

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