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(Primary Sjogren Syndrome; Secondary Sjogren Syndrome)
by Editorial Staff and Contributors
Sjogren syndrome is an inflammatory disease. The immune system destroys cells in exocrine glands. It occurs most often in the tear and salivary glands. It is a lifelong condition. There are 2 types:
The causes of Sjogren are unknown. Contributing factors may include:
Risk Factors TOP
Women and people between the ages of 40-60 years old are at increased risk. Factors that increase your risk for Sjogren include:
Symptoms may include:
In some cases, other parts of the body are affected as well. These include:
You will be asked about your symptoms and medical history. A physical exam will be done. You may be referred to a specialist. You may also be referred to a dentist for an exam.
Your bodily fluids and tissues may be tested. This can be done with:
Your eyes may be tested. This can be done with:
Images may also be taken of your bodily structures. This can be done with:
There is no cure for Sjogren syndrome. No treatment can restore the ability of the glands to produce moisture. The goal of treatment is to relieve symptoms.
You may be given medications to relieve:
Lifestyle changes may help to relieve symptoms. These include:
There are no guidelines for preventing Sjogren syndrome. The cause is unknown.
American Autoimmune Related Diseases Association
Sjogren's Syndrome Foundation
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Papas, et al. Successful treatment of dry mouth and dry eye symptoms in Sjogren's syndrome patients with oral pilocarpine: a randomized, placebo-controlled, dose-adjustment study. J Clin Rheumatol. 2004;10:169-177.
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Sjogren syndrome. EBSCO DynaMed Plus website. Available at: http://www.dynamed.com/topics/dmp~AN~T116074/Sjogren-syndrome. Updated August 15, 2017. Accessed December 21, 2017.
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7/7/2014 DynaMed Plus Systematic Literature Surveillance http://www.dynamed.com/topics/dmp~AN~T116074/Sjogren-syndrome: Liang Y, Yang Z, et al. Primary Sjogren's syndrome and malignancy risk: a systematic review and meta-analysis. Ann Rheum Dis. 2014 Jun;73(6):1151-1156.
11/9/2015 DynaMed Plus Systematic Literature Surveillance http://www.dynamed.com/topics/dmp~AN~T116074/Sjogren-syndrome: Kuo CF, Grainge MJ, Valdes AM, et al. Familial aggregation of systemic lupus erythematosus and coaggregation of autoimmune diseases in affected families. JAMA Intern Med. 2015;175(9):1518-1526.
2/22/2017 DynaMed Plus Systematic Literature Surveillance http://www.dynamed.com/topics/dmp~AN~T116074/Sjogren-syndrome: Luciano N, Baldini, Tarantini G, et al. Ultrasonography of major salivary glands: a highly specific tool for distinguishing primary Sjögren's syndrome from undifferentiated connective tissue diseases. Rheumatology (Oxford). 2015;54(12):2198-2204.
Last reviewed December 2017 by Kari Kassir, MD
Last Updated: 2/22/2017
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