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Granulomatosis with Polyangiitis
by Annie Stuart
Granulomatosis with polyangiitis is a rare disease that causes the walls of blood vessels to become inflamed, a condition called vasculitis. This limits blood flow to tissues and can affect any organ.
Granulomatosis with polyangiitis is a type of autoimmune disease. This means the body’s immune system attacks its own tissues. The cause is unknown.
Risk Factors TOP
Granulomatosis with polyangiitis does not appear to be passed from one generation to the next. It is more common in Caucasians, and in people of middle age.
Symptoms and their severity vary from one person to another. In most cases, ear, nose, and throat symptoms appear first. These symptoms do not respond to normal treatment and worsen over time.
Granulomatosis with polyangiitis can cause common cold- or flu-like symptoms such as:
Common respiratory tract symptoms associated with granulomatosis with polyangiitis may include:
You will be asked about your symptoms and medical history. A physical exam will be done. The doctor may do tests to rule out other conditions, determine which organs are involved, or to confirm the diagnosis. Tests may include:
Images may be needed of your bodily structures. This can be done with:
The outlook is good with proper treatment, but without it, granulomatosis with polyangiitis is fatal. Granulomatosis with polyangiitis is treated with medications. Some are used to induce remission, while others are used for maintenance when remission is achieved.
Your doctor may recommend 1 or more of the following:
There are no current guidelines to prevent granulomatosis with polyangiitis.
National Institute of Allergy and Infectious Diseases (NIH)
Public Health Agency of Canada
Granulomatosis with polyangiitis. EBSCO DynaMed Plus website. Available at: http://www.dynamed.... Updated June 17, 2016. Accessed September 29, 2016.
Granulomatosis with polyangiitis. National Institute of Allergy and Infectious Diseases website. Available at: https://www.niaid.nih.gov/topics/gpa/pages/default.aspx. Updated October 29, 2013. Accessed June 13, 2016.
What is granulomatosis with polyangiitis/Wegener's? Vasculitis Foundation website. Available at: https://www.vasculitisfoundation.org/mcm_faq/what-is-granulomatosis-with-polyangiitiswegeners. Accessed June 13, 2016.
Last reviewed June 2016 by Michael J. Fucci, DO, FACC
Last Updated: 5/11/2013
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