Levoleucovorin injection is used to prevent harmful effects of methotrexate (Trexall) when methotrexate is used to treat osteosarcoma (cancer that forms in bones). Levoleucovorin injection is also used to treat people who have accidentally received an overdose of methotrexate or similar medications or who are not able to eliminate these medications properly from their bodies. Levoleucovorin injection is also used together with fluorouracil (5-FU, a chemotherapy medication) to treat colorectal cancer (cancer that begins in the large intestine) that has spread to other parts of the body. Levoleucovorin injection is in a class of medications called folic acid analogs. It works to prevent the harmful effects of methotrexate by protecting healthy cells, while allowing methotrexate to enter and kill cancer cells. It works to treat colorectal cancer by increasing the effects of fluorouracil.
Levoleucovorin injection comes as a solution (liquid) and a powder to be mixed with liquid and injected intravenously (into a vein) by a doctor or nurse in a hospital or medical office. When levoleucovorin is used to prevent the harmful effects of methotrexate or treat an overdose of methotrexate, it is usually given every 6 hours, beginning 24 hours after a dose of methotrexate or as soon as possible after an overdose and continuing until laboratory tests show it is no longer needed. When levoleucovorin injection is used to treat colorectal cancer, it is usually given once a day for 5 days in a row as part of a dosing cycle that may be repeated every 4 to 5 weeks.
This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.
Before receiving levoleucovorin injection,
Unless your doctor tells you otherwise, continue your normal diet.
Levoleucovorin injection and the medication(s) it is given with may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
Some side effects can be serious. If you experience any of these symptoms or those in the SPECIAL PRECAUTIONS section, call your doctor immediately or get emergency medical treatment:
Levoleucovorin injection may cause other side effects. Call your doctor if you have any unusual problems while receiving this medication.
If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online ( Web Site ) or by phone (1-800-332-1088).
In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at Web Site. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.
Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your body's response to levoleucovorin injection.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
AHFS® Consumer Medication Information. © Copyright, The American Society of Health-System Pharmacists, Inc., 7272 Wisconsin Avenue, Bethesda, Maryland. All Rights Reserved. Duplication for commercial use must be authorized by ASHP.
Selected Revisions: March 15, 2019.