is a gradually progressive degenerative disorder of the central nervous system. Parkinson's disease belongs to a group of conditions called movement disorders. There are 4 characteristic problems caused by Parkinson disease, including tremor at rest, balance problems, stiffness, and slowness of movement.
Parkinson disease occurs when areas of the brain, including an area called the substantia nigra, is slowly destroyed. The exact reason for this destruction is not completely known. In some people, it may be related to genetics, environment, or a combination of both. The end result is a deprivation in the brain of an important neurochemical, called dopamine. Dopamine helps regulate movement, and its loss leads to increased tone, rigidity, and slowness of movement. Lack of dopamine results in the symptoms associated with Parkinson disease.
NINDS Parkinson's disease information page. National Institute of Neurological Disorders and Stroke website. Available at: http://www.ninds.nih.gov/disorders/parkinsons_disease/parkinsons_disease.htm. Updated July 26, 2016. Accessed November 29, 2016.
Obeso JA, Rodriguez-Oroz MC, Goetz CG, et al. Missing pieces in the Parkinson’s disease puzzle. Nature Medicine. 2010;16(6):653-661.
Parkinson disease. Merck Manual Professional Version website. Available at: http://www.merckmanuals.com/professional/neurologic-disorders/movement-and-cerebellar-disorders/parkinson-disease. Updated September 2015. Accessed November 29, 2016.
Parkinson's disease. American Association of Neurological Surgeons website. Available at: http://www.aans.org/en/Patient%20Information/Conditions%20and%20Treatments/Parkinsons%20Disease.aspx. Accessed November 29, 2016.
What is Parkinson's disease? Parkinson’s Disease Foundation website. Available at: http://www.pdf.org/about_pd. Accessed November 29, 2016.
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