Gilbert syndrome is a genetic liver disorder. It causes levels of bilirubin to rise above normal levels. Bilirubin is a yellow chemical by-product of hemoglobin. Hemoglobin is the red pigment in blood cells that is usually excreted by the liver as bile.
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Gilbert syndrome is usually caused by an inherited genetic abnormality. Symptoms occur when there is an interference with the liver enzyme that is important in the elimination of bilirubin. This causes the levels of bilirubin to increase in the blood, which may produce symptoms such as jaundice.
Risk Factors ^
Gilbert syndrome is more common in males, and in those with a family history.
Often, there are no symptoms of Gilbert syndrome. However, people who do have symptoms may experience:
- Yellowing of the skin known as jaundice
- Jaundice of the whites of the eyes
- Abdominal pain
- Loss of appetite
- Fatigue and weakness
- Darkening of the urine
You will be asked about your symptoms and medical history. A physical exam will be done. Tests may include:
- Blood tests
- Reticulocyte count
- Total and direct bilirubin
- Liver function tests
No treatment is necessary for Gilbert syndrome. Usually, symptoms come and go.
American Liver Foundation
National Institute of Diabetes and Digestive and Kidney Diseases
Gilbert syndrome. American Liver Foundation website. Available at: http://www.liverfoundation.org/abouttheliver/info/gilbertsyndrome. Updated January 14, 2015. Accessed March 10, 2016.
Gilbert syndrome. EBSCO DynaMed Plus website. Available at:http://www.dynamed.com/topics/dmp~AN~T115578/Gilbert-syndrome. Updated May 5, 2011. Acessed March 10, 2016.
Gilbert syndrome. Genetics Home Reference website. Available at: http://ghr.nlm.nih.gov/condition/gilbert-syndrome. Updated February 2012. Accessed March 10, 2016.
Last reviewed March 2016 by Kari Kassir, MD Last Updated: 3/18/2013