Fine Needle Biopsy
by Amy Scholten, MPH
A biopsy is a procedure to remove a tissue sample. In a fine needle biopsy (FNB), fluid and cells are removed with a thin, hollow needle.
Reasons for Procedure
FNB is used to look at the tissue of an organ or tumor. The sample may show unusual cells, disease, infection, or inflammation.
It may also be done to find out how certain treatments are working.
Problems are rare, but all procedures have some risk. The doctor will go over some problems that could happen, such as:
Things that may raise the risk of problems are:
What to Expect
Prior to Procedure
The medical team may meet with you to talk about:
The doctor may give:
Description of the Procedure
You may be asked to drink contrast material. This will make images clearer.
Images may be taken to help guide the needle. This may be done with an ultrasound, x-ray, or CT scan.
You will be put in a position that helps the doctor see the site. You will be asked to stay still. A thin, hollow needle will be inserted through the skin to the site. The needle may need to be inserted more than once. The images may be checked to make sure the needle is in the right place. Tissue or fluid will be drawn through the needle. The needle will be removed after the sample is taken. The site will be bandaged. The sample will be sent to a lab.
How Long Will It Take?
How long it takes will depend on the site:
Will It Hurt?
Mild pain is common in the first 2 days. Medicine and home care can help.
Average Hospital Stay
Most people can go home the same day. If you have any problems, you may need to stay longer.
At the Care Center
You will be able to go home when the anesthesia wears off.
Activity should be limited for the rest of the day. It will take two days for the discomfort to go away.
Call Your Doctor
Call your doctor if you are not getting better or you have:
If you think you have an emergency, call for medical help right away.
Family Doctor—American Academy of Family Physicians
National Cancer Institute
Canadian Cancer Society
Biopsy for breast cancer diagnosis: Fine needle aspiration biopsy. UCSF Health website. Available at: https://www.ucsfhealth.org/education/biopsy_for_breast_cancer_diagnosis/fine_needle_aspiration_biopsy/index.html. Accessed January 13, 2021.
Fine needle aspiration biopsy. American Academy of Otolaryngology—Head and Neck Surgery website. Available at:
...(Click grey area to select URL)
Accessed January 13, 2021.
Palpable mass evaluation in women. EBSCO DynaMed website. Available at: https://www.dynamed.com/evaluation/palpable-breast-mass-evaluation-in-women. Accessed January 13, 2021.
Tani E, Fuentes-Martinez N, et. al. A review of the use of fine-needle aspiration biopsy of mammary tumors for diagnosis and research. Acta Cytologica 2017;61:305-315.
Last reviewed February 2021 by EBSCO Medical Review Board Marcin Chwistek, MD
Last Updated: 1/13/2021