(Androblastoma; Sertoli-Leydig Cell Tumor of the Ovary)
by Cynthia M. Johnson, MA
An arrhenoblastoma is a rare type of ovarian tumor. The tumor cells release a male sex hormone called testosterone.
The cause is not known.
This health problem can happen in girls and women of all age groups. However, it is more common in women between 20 and 30 years of age.
In many women, irregular or absent menstrual periods are the only symptom.
In others, the male hormones released by the tumor may cause:
The doctor will ask about your symptoms and health history. A physical exam will be done.
Blood tests will be done to check hormone levels.
Images may be taken of the pelvis. This can be done with ultrasound.
Surgery will be done to remove the tumor. Cancer that has spread may also be treated with:
There are no known guidelines to prevent this health problem.
The Endocrine Society
Ovarian Cancer Research Fund Alliance
Canadian Cancer Society
Ovarian Cancer Canada
Colombo N, Parma G, et al. Management of ovarian stromal cell tumors. J Clin Oncol. 2007;20:2944-2951.
McCluggage WG, McKenna M, et al. CD56 is a sensitive and diagnostically useful immunohistochemical marker of ovarian sex cord stromal tumor. Int J Gyn Pathol. 2007;26:322-327.
Sachdeva P, Arora R, et al. Cell tumor: a rare ovarian neoplasm. Gynecologic Endocrinology. 2008;24(4):230-234.
Sertoli-leydig cell tumors. Genetic and Rare Diseases Information Center—National Institutes of Health website. Available at: https://rarediseases.info.nih.gov/diseases/9967/sertoli-leydig-cell-tumors. Accessed February 23, 2021.
Types of ovarian tumors. Johns Hopkins Medicine Pathology website. Available at: https://pathology.jhu.edu/ovarian-cancer/types-of-tumors. Accessed February 23, 2021.
Last reviewed December 2020 by EBSCO Medical Review Board Beverly Siegal, MD, FACOG
Last Updated: 2/23/2021