by Rick Alan
Kaposi's sarcoma (KS) is a form of cancer. It can cause lesions on the skin, mucus membranes, or internal organs such as the gastrointestinal tract and lungs.
KS can be classified according to the group of people it affects:
Cancer occurs when cells in the body divide without control or order. If cells keep dividing, a mass of tissue forms. This mass is called a growth or tumor. Malignant tumors can invade and destroy nearby tissue. Some types of cancer will eventually spread to other parts of the body.
KS is caused by an infection with a specific virus. The virus is called human herpes virus 8 or Kaposi sarcoma herpesvirus (KSHV). Most people infected with the virus will not get KS. KS most often develops in people who have the virus and also have a weakened immune system.
Factors that may increase the chances of KS:
KS lesions may develop anywhere on the body. They tend to be raised blotches or nodules which may be purple, brown, red, or pink.
Lesions in the lungs can also cause breathing problems.
You will be asked about your symptoms and medical history. A physical exam will be will be done If you have skin lesions, the doctor may base the diagnosis on this. If you have bleeding, pain, or weight loss, you may need more tests to find out if you have KS.
Tests may include:
Talk to your doctor about the best treatment plan for you. Treatment depends on the type of KS, how much it has spread, and how well a person's immune system is functioning. Treatments include one or more of the following:
Local therapy is useful if there are a few lesions together in a small area. Treatments options may include:
These treatments do not prevent new lesions from developing.
Surgery is an option if there are a few, small lesions. Surgical options include either:
Photodynamic therapy is a type of light therapy. A special medication is applied to the skin to make it sensitive to light. The skin is later exposed to a special light. The sensitivity to the light kills the cancer cells.
High-energy radiation is used to kill cancer cells. The number of treatments depends on the size and location of the lesions. It can also be used to treat pain and swelling. Different types of radiation therapy may include:
Radiation therapy schedules may vary, but it is generally done over a period of several weeks.
This therapy is used to treat HIV infection and restore immune function. In some, it may be effective against KS.
Chemotherapy is the use of drugs to kill cancer cells. It may be given in many forms, including pill, injection, and via a catheter. The drugs enter the bloodstream and travel through the body killing mostly cancer cells. Some healthy cells are also killed.
In some cases, the drugs can be injected directly into a lesion.
This is the use of drugs to enhance the body's own immune system. They are used to increase or restore the body's natural defenses against cancer. Immunotherapy of KS is done with interferon.
There are no current guidelines to prevent KS.
American Cancer Society
National Cancer Institute
Canadian AIDS Society
Canadian Cancer Society
Kaposi sarcoma. American Cancer Society website. Available at: https://www.cancer.org/cancer/kaposi-sarcoma.html. Accessed January 29, 2021.
Kaposi sarcoma. EBSCO DynaMed website. Available at:
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Accessed January 29, 2021.
Kaposi sarcoma treatment (PDQ)—patient version. National Cancer Institute website. Available at: https://www.cancer.gov/types/soft-tissue-sarcoma/patient/kaposi-treatment-pdq. Accessed January 29, 2021.
Last reviewed September 2020 by EBSCO Medical Review Board Mohei Abouzied, MD, FACP