Temozolomide is used to treat certain types of brain tumors. Temozolomide is in a class of medications called alkylating agents. It works by slowing or stopping the growth of cancer cells in your body.
Temozolomide injection comes as a powder to be added to fluid and injected over 90 minutes intravenously (into a vein) by a doctor or nurse. It is usually injected once a day. For some types of brain tumors, temozolomide is given daily for 42 to 49 days. Then, after a 28-day break, it may be given once a day for 5 days in a row, followed by a 23-day break before repeating the next dosage cycle. For treatment of other types of brain tumors, temozolomide is given once a day for 5 days in a row, followed by a 23-day break before repeating the next dosage cycle. The length of treatment depends on the how well your body responds to it and the type of cancer that you have.
Your doctor may need to delay your treatment or adjust your dose depending on your response to treatment and any side effects that you experience. Talk to your doctor about how you are feeling during your treatment with temozolomide.
Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.
This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.
Before receiving temozolomide,
Unless your doctor tells you otherwise, continue your normal diet.
Temozolomide may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately or get emergency medical treatment:
Temozolomide may increase the risk that you will develop other cancers. Talk to your doctor about the risks of taking temozolomide.
Temozolomide may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.
If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online ( Web Site ) or by phone (1-800-332-1088).
In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at Web Site. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.
Symptoms of overdose may include the following:
Keep all appointments with your doctor and the laboratory. Your doctor will order laboratory tests before, during, and after your treatment to check your body's response and to temozolomide to see if your blood cells are affected by this drug.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
AHFS® Consumer Medication Information. © Copyright, The American Society of Health-System Pharmacists, Inc., 7272 Wisconsin Avenue, Bethesda, Maryland. All Rights Reserved. Duplication for commercial use must be authorized by ASHP.
Selected Revisions: February 15, 2013.