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Ashwagandha is a plant that has been used to treat fatigue and improve well-being. Its root and berry can be taken as a pill, powder, or extract.


2 to 5 grams once per day

What Research Shows

May Be Effective

  • Infertility (male) —may improve sperm qualityA1,A2

Editorial process and description of evidence categories can be found at EBSCO NAT Editorial Process.

Safety Notes

It is likely safe to take small doses of ashwagandha for a short period of time. Not enough studies have been done to say whether it is safe to use for a long period.


Talk to your doctor about any supplements or therapy you would like to use. Ashwagandha can interfere with treatment or make conditions worse, such as:

  • Ashwagandha may interact with digoxin. People with heart failure and rhythm problems should talk to their doctor before taking it.



A1. Ahmad MK, Mahdi AA, et al. Withania somnifera improves semen quality by regulating reproductive hormone levels and oxidative stress in seminal plasma of infertile males. Fertil Steril. 2010;94(3):989-996.

A2. Gupta A, Mahdi AA, et al. Efficacy of Withania somnifera on seminal plasma metabolites of infertile males: a proton NMR study at 800 MHz. J Ethnopharmacol. 2013;149(1):208-214.

Last reviewed July 2019 by EBSCO NAT Review Board Eric Hurwitz, DC  Last Updated: 9/9/2019