Brand Name(s):

  • Xepi®

WHY is this medicine prescribed?

Ozenoxacin is used to treat impetigo (a skin infection caused by bacteria) in adults and children 2 months of age and older. Ozenoxacin is in a class of medications called antibacterials. It works by killing and stopping the growth of bacteria on the skin.

HOW should this medicine be used?

Ozenoxacin comes as a cream to be applied in a thin layer to the skin. It is usually used twice a day for 5 days. Apply ozenoxacin at around the same times every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Use ozenoxacin exactly as directed. Do not use more or less of it or use it more often than prescribed by your doctor.

The infected area of the skin should begin to look better during the first few days of treatment with ozenoxacin. If your condition does not improve after using this medication for 3 days or gets worse, call your doctor.

Ozenoxacin is for use only on the infected area of the skin. Do not let ozenoxacin cream get into your eyes, or inside your mouth, or nose, or inside the female genital area. Do not swallow this medication.

After applying the cream, you may cover the treated area with a clean bandage or gauze.

Wash your hands after applying ozenoxacin if your hands are not the area that is being treated.

Use ozenoxacin for as long as your doctor recommends, even if the infection looks better. If you stop using ozenoxacin too soon or skip doses, the infection may not be completely gone and the bacteria could become difficult to treat with another antibiotic.

Are there OTHER USES for this medicine?

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

What SPECIAL PRECAUTIONS should I follow?

Before taking ozenoxacin,

  • tell your doctor and pharmacist if you are allergic to ozenoxacin, any other medications, or any of the ingredients in ozenoxacin cream. Ask your pharmacist for a list of the ingredients.
  • tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements and herbal products you are taking or plan to take. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
  • tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while taking ozenoxacin, call your doctor.

What SPECIAL DIETARY instructions should I follow?

Unless your doctor tells you otherwise, continue your normal diet.

What should I do IF I FORGET to take a dose?

Apply the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not apply extra cream to make up for a missed dose.

What SIDE EFFECTS can this medicine cause?

Ozenoxacin may cause side effects. Some side effects can be serious. If you experience any of these symptoms call your doctor immediately:

  • a new rash or infection at or near the area being treated

Ozenoxacin may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online ( Web Site ) or by phone (1-800-332-1088).

What should I know about STORAGE and DISPOSAL of this medication?

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture.

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. Web Site

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website ( Web Site) for more information if you do not have access to a take-back program.

What OTHER INFORMATION should I know?

Keep all appointments with your doctor.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

AHFS® Consumer Medication Information. © Copyright, The American Society of Health-System Pharmacists, Inc., 7272 Wisconsin Avenue, Bethesda, Maryland. All Rights Reserved. Duplication for commercial use must be authorized by ASHP.

Selected Revisions: March 15, 2018.