Atezolizumab injection is used to treat certain types of urothelial cancer (cancer of the lining of the bladder and other parts of the urinary tract) that has spread or cannot be removed by surgery in people unable to receive platinum-containing chemotherapy (carboplatin, cisplatin) or whose condition has worsened during or after treatment with platinum-containing chemotherapy medication. Atezolizumab injection is also used together with other chemotherapy medications as a first treatment for certain types of non-small cell lung cancer (NSCLC) that has spread to other parts of the body. It is also used to treat NSCLC that has spread to other parts of the body and that has worsened during or after treatment with other chemotherapy medications. Atezolizumab injection is also used together with other chemotherapy medications as a first treatment for a certain type of small cell lung cancer (SCLC) that has spread thoughout the lung or to other parts of the body. It is also used together with other chemotherapy medications as a treatment for a certain type of breast cancer that has spread to other parts of the body or can not be removed by surgery. Atezolizumab injection is in a class of medications called monoclonal antibodies. It works by blocking the action of a certain protein in cancer cells. This helps the person's immune system to fight against the cancer cells, and helps to slow tumor growth.
Atezolizumab injection comes as liquid to be injected into a vein over 30 to 60 minutes by a doctor or nurse in a hospital or medical facility. When atezolizumab injection is used to treat urothelial cancer, non-small cell lung cancer, or small cell lung cancer, it is usually injected once every 3 weeks. When atezolizumab injection is used to treat breast cancer it is usually injected on days 1 and 15 as part of a 4 week cycle. The length of your treatment depends on how well your body responds to the medication and the side effects that you experience.
Atezolizumab injection may cause serious reactions during the infusion of the medication. A doctor or nurse will monitor you carefully while you are receiving the medication. If you experience any of the following symptoms, tell your doctor immediately: flushing, fever, chills, shaking, dizziness, feeling faint, shortness of breath, difficulty breathing, itching, rash, back or neck pain, or swelling of the face or lips.
Your doctor may need to slow down your infusion, delay or stop your treatment, or treat you with other medications if you experience certain side effects. Be sure to tell your doctor how you are feeling during your treatment with atezolizumab injection.
Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with atezolizumab injection and each time you receive the medication. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website ( Web Site) or the manufacturer's website to obtain the Medication Guide.
This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.
Before receiving atezolizumab injection,
Unless your doctor tells you otherwise, continue your normal diet.
Atezolizumab injection may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
Some side effects can be serious. If you experience any of these symptoms call your doctor immediately or get emergency medical treatment:
Atezolizumab injection may cause other side effects. Call your doctor if you have any unusual problems while receiving this medication.
If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online ( Web Site ) or by phone (1-800-332-1088).
In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at Web Site. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.
Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests before and during your treatment with atezolizumab injection to check your body's response to the medication. For some conditions, your doctor will order a lab test before you begin your treatment to see whether your cancer can be treated with atezolizumab.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
AHFS® Consumer Medication Information. © Copyright, The American Society of Health-System Pharmacists, Inc., 7272 Wisconsin Avenue, Bethesda, Maryland. All Rights Reserved. Duplication for commercial use must be authorized by ASHP.
Selected Revisions: April 15, 2019.