Inflammatory Bowel Disease (IBD)
Inflammatory bowel disease (IBD) is inflammation in the lining and sometimes the wall of the intestine. It includes ulcerative colitis and crohns disease. It can cause diarrhea, belly pain, and rectal bleeding.
It is managed with medicine and healthy habits. Some people may need surgery. Natural therapies have been used to ease digestive upset. They should not be used in place of standard care.
May Be Effective
Unlikely to Be Effective
Not Enough Data to Assess
Editorial process and description of evidence categories can be found at EBSCO NAT Editorial Process.
Herbs and Supplements to Be Used With Caution
Talk to your doctor about any supplements or therapy you would like to use. Some may get in the way of treatment. They can also make illness worse or cause new problems. Examples include:
Herbs and Supplements
A1. Gerhardt H, Seifert F, et al. [Therapy of active Crohn disease with Boswellia serrata extract H 15]. Z Gastroenterol. 2001;39(1):11-17.
A2. Hanai H, Iida T, et al. Curcumin maintenance therapy for ulcerative colitis: randomized, multicenter, double-blind, placebo-controlled trial. Clin Gastroenterol Hepatol. 2006;4(12):1502-1506.
A3. Mallon P, McKay D, et al. Probiotics for induction of remission in ulcerative colitis. Cochrane Database Syst Rev. 2007 Oct 17;(4):CD005573.
A4. Turner D, Zlotkin SH, et al. Omega 3 fatty acids (fish oil) for maintenance of remission in Crohn’s disease. Cochrane Database Syst Rev. 2007;(2):CD006320.
A5. De Ley M, de Vos R, et al. Fish oil for induction of remission in ulcerative colitis. Cochrane Database Syst Rev. 2007 Oct 17;(4):CD005986.
A6. Schneider A, Streitberger K, et al. Acupuncture treatment in gastrointestinal diseases: a systematic review. World J Gastroenterol. 2007 Jul 7;13(25):3417-3424.
A7. Doherty GA, Bennett GC, et al. Meta-analysis: targeting the intestinal microbiota in prophylaxis for post-operative Crohn’s disease. Aliment Pharmacol Ther. 2010;31(8):802-809.
A8. Tang T, Targan SR, et al. Randomized clinical trial: herbal extract HMPL-004 in active ulcerative colitis – a double-blind comparison with sustained release mesalazine. Aliment Pharmacol Ther. 2011;33(2):194-202.
A9. Nicholson I, Dalzell AM, et al. Vitamin D as a therapy for colitis: a systematic review. J Crohns Colitis. 2012 May;6(4):405-411.
A10. Cabré E, Mañosa M, et al. Omega-3 fatty acids and inflammatory bowel diseases - a systematic review. Br J Nutr. 2012 Jun;107 Suppl 2:S240-52.
A11. Sandborn WJ, Targan SR, et al. Andrographis paniculate extract (HMPL-004) for active ulcerative colitis. Am J Gastroenterol. 2013;108(1):90-98.
A12. Swan K, Allen PJ. Omega-3 fatty acid for the treatment and remission of Crohn's disease. J Complement Integr Med. 2013 May 7;10.
A13. Shen J, Zuo ZX, et al. Effects of probiotics on inducing remission and maintain therapy in ulcerative colitis, Crohn’s disease, and pouchitis: meta-analysis of randomized controlled trials. Inflamm Bowel Dis. 2014;20(1):21-35.
A14. Akobeng AK, Elawad M, et al. Glutamine for induction of remission in Crohn's disease. Cochrane Database Syst Rev. 2016 Feb 8;2:CD007348.
A15. Rossi RE, Whyand T, et al. The role of dietary supplements in inflammatory bowel disease: a systematic review. Eur J Gastroenterol Hepatol. 2016 Dec;28(12):1357-1364.
A16. Derwa Y, Gracie DJ, et al. Systematic review with meta-analysis: the efficacy of probiotics in inflammatory bowel disease. Aliment Pharmacol Ther. 2017;46(4):389-400.
A17. Schneider A, Hossain I, et al. Comparison of remicade to curcumin for the treatment of Crohn's disease: A systematic review. Complement Ther Med. 2017 Aug;33:32-38.
A18. Kafil TS, Nguyen TM, et al. Cannabis for the treatment of Crohn’s disease. Cochrane Database Syst Rev. 2018;11:CD012853.
A19. Li HB, Chen MY, et al. Efficacy and safety of Kangfuxin liquid combined with aminosalicylic acid for the treatment of ulcerative colitis: A systematic review and meta-analysis. Medicine (Baltimore). 2018 May;97(21):e10807.
A20. Kafil TS, Nguyen TM, et al. Cannabis for the treatment of ulcerative colitis. Cochrane Database Syst Rev. 2018 Nov 8;11:CD012954.
A21. Li J, Chen N, et al. Efficacy of vitamin D in treatment of inflammatory bowel disease: A meta-analysis. Medicine (Baltimore). 2018 Nov;97(46):e12662.
B. Other Therapies
B1. Lee DH, Kim JI, et al. Moxibustion for ulcerative colitis: a systematic review and meta-analysis. BMC Gastroenterol. 2010 Apr 7;10:36.
B2. Jewell S, Hoffman A, et al. A randomized controlled trial of mindfulness-based stress reduction to prevent flare-up in patients with inactive ulcerative colitis. Digestion. 2014;89(2):142-155.
C1. Wedlake L, Slack N, et al. Fiber in the treatment and maintenance of inflammatory bowel disease: a systematic review of randomized controlled trials. Inflamm Bowel Dis. 2014 Mar;20(3):576-586.
C2. Thies F, Masson LF, et al. Oats and bowel disease: a systematic literature review. Br J Nutr. 2014 Oct;112 Suppl 2:S31-43.
C3. Limketkai BN, Iheozor-Ejiofor Z, et al. Dietary interventions for induction and maintenance of remission in inflammatory bowel disease. Cochrane Database Syst Rev. 2019 Feb 8;2:CD012839.
Last reviewed February 2020 by EBSCO NAT Review Board Eric Hurwitz, DC
Last Updated: 5/26/2020
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