Bloqueadores de los Canales del Calcio

Canal de calcio - los bloqueadores son usados para tratar la hipertensión, angina, arritmias cardiacas y otras enfermedades cardiacas relacionadas.

Las medicinas en esta familia incluyen

  • amlodipina (Norvasc)
  • Clorohidrato de bepridil (Vascor)
  • diltiazem (Cardizem, Cardizem CD, Cardizem SR, Dilacor XR, Tiamate, Tiazac)
  • felodipino (Plendil)
  • isradipina (Dynacirc, Dynacirc CR)
  • hidrocloruro de nicardipina (Cardene, Cardene SR)
  • nifedipina (Procardia, Procardia XL, Adalat, Adalat CC)
  • nimodipina (Nimotop)
  • nisoldipina (Sular)
  • verapamil (Calan, Calan SR, Covera-HS, Isoptin, Isoptin SR, Verelan)
  • y otros
Posible Reducción de la Acción del Medicamento

Tomar suplementos de calcio y vitamina D podría interferir con algunos de los efectos de los bloqueadores del canal de calcio.1 - 7

Según un estudio en ratas, el extracto de ginkgo puede causar que el cuerpo metabolice nicardipina (un bloqueador del canal de calcio) más rápidamente, reduciendo de esa manera sus efectos.8


1. Bar-Or D and Gasiel Y. Calcium and calciferol antagonise effect of verapamil in atrial fibrillation. Br Med J (Clin Res Ed) 282: 1585 - 1586, 1981.

2. Hariman RJ, Mangiardi LM, McAllister RG Jr, et al. Reversal of the cardiovascular effects of verapamil by calcium and sodium: differences between electrophysiologic and hemodynamic responses. Circulation 59: 797 - 804, 1979.

3. Guadagnino V, Greengart A, Hollander G, et al. Treatment of severe left ventricular dysfunction with calcium chloride in patients receiving verapamil. J Clin Pharmacol 27: 407 - 409, 1987.

4. Salerno DM, Anderson B, Sharkey PJ, et al. Intravenous verapamil for treatment of multifocal atrial tachycardia with and without calcium pretreatment. Ann Intern Med 107: 623 - 628, 1987.

5. Luscher TF, Noll G, Sturmer T, et al. Calcium gluconate in severe verapamil intoxication. N Engl J Med 330: 718 - 720, 1994.

6. Orr GM, Bodansky HJ, Dymond DS, et al. Fatal verapamil overdose. Lancet 2: 1218 - 1219, 1982.

7. Kuhn M and Schriger DL. Low-dose calcium pretreatment to prevent verapamil-induced hypotension. Am Heart J 124: 231 - 232, 1992.

8. Shinozuka K, Umegaki K, Kubota Y, et al. Feeding of Ginkgo biloba extract (GBE) enhances gene expression of hepatic cytochrome P-450 and attenuates the hypotensive effect of nicardipine in rats. Life Sci. 2002;70:2783-2792.

Ultima revisión agosto 2013 por EBSCO CAM Review Board
Last Updated: 8/22/2013

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