Esophageal Variceal Injection
(Sclerotherapy for Esophageal Varices; Endoscopic Sclerotherapy)
by Daus Mahnke, MD
Esophageal varices are abnormal blood vessels that develop in the esophagus. They have abnormally thin walls and the blood pressure within them is very high. This combination makes esophageal varices dangerous, because they can burst and cause life-threatening bleeding.
Esophageal variceal injection is a procedure to either stop active bleeding or prevent future bleeding. During the procedure, medication is injected into or alongside esophageal varices. When injecting into the vein, the medication causes blood clots to form, blocking the vein from bleeding. When injected alongside the vein, the swelling in the area compresses the vein, preventing it from bleeding.
The procedure is also known as sclerotherapy.
Reasons for Procedure TOP
Esophageal varices can be life-threatening. Esophageal variceal injection is a procedure that can be done to stop active bleeding from esophageal varices and prevent rebleeding.
Possible Complications TOP
Problems from the procedure are rare, but all procedures have some risk. Your doctor will review potential problems, like:
Some factors that may increase the risk of complications include:
What to Expect TOP
Prior to Procedure
Description of the Procedure TOP
For this procedure, you will lie on your left side. A mouthpiece will be placed to help keep your mouth open. An assistant will be in the room to monitor your breathing and heartbeat. You may also be given oxygen through your nose. A suction tube will be used to clear the saliva and other fluids from your mouth.
A lubricated endoscope will be placed into your mouth. It will be passed down your throat and into your esophagus. The scope will have a small light and a camera. Images will display on a video monitor. Air will be passed through the scope to help your doctor see your esophagus. The enlarged vein will be located. If needed, the endoscope can be passed all the way down into the stomach and upper intestines.
When near the varices, a flexible needle will be passed through the scope. The needle will be used to inject medication into the varices. If needed, your doctor may do many injections during one procedure.
Instruments can also be passed through the scope to apply rubber band-like devices. The rubber band ties off the varices. This will prevent future bleeding. This is called band ligation.
How Long Will It Take? TOP
About 30-60 minutes
How Much Will It Hurt? TOP
During the procedure, you may feel discomfort in your throat. After the procedure, your throat may be sore for a few days. In addition, you may feel bloated and need to belch. It may also be painful to swallow for a couple of days after the procedure.
Post-procedure Care TOP
Unless otherwise instructed, resume your normal diet and medications. Rest for the remainder of the day. Do not drive for at least 24 hours after the procedure. Do not make any life-changing decisions.
After this procedure, you will have a smaller chance of bleeding from your esophageal varices. However, it is still possible to bleed from varices that have been injected.
Follow up as directed by your doctor. More than one procedure may be required.
Call Your Doctor TOP
Contact your doctor if your recovery is not progressing as expected or you develop complications, such as:
If you think you have an emergency, call for emergency medical services right away.
American College of Gastroenterology
American Gastroenterological Association
Canadian Association of Gastroenterology
Berry PA, Wendon JA. The management of severe alcoholic liver disease and variceal bleeding in the intensive care unit. Curr Opin Crit Care. 2006;12(2):171-177.
Garcia-Tsao G, Sanyal AJ, et al. Prevention and management of gastroesophageal varices and variceal hemorrhage in cirrhosis. Am J Gastroenterol. 2007;102(9):2086-2102.
Gastroesophageal varices. EBSCO DynaMed website. Available at:
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Updated May 13, 2013. Accessed July 12, 2013.
Park WG, Yeh RW. Injection therapies for variceal bleeding disorders of the GI tract. Gastrointest Endosc. 2008;67(2):313-323.
Technology Assessment Committee, Croffie J, Somogyi L, et al. Sclerosing agents for use in GI endoscopy. Gastrointest Endosc. 2007;66(1):1-6.
Last reviewed March 2016 by Daus Mahnke, MD
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