Calcium Pyrophosphate Dihydrate Deposition Disease

(CPPD; Pseudogout; Chondrocalcinosis)

Definition

Calcium pyrophosphate dihydrate deposition disease (CPPD) is a build up of calcium crystals in the joints. These crystals cause inflammation in the joints. This can cause problems that are like arthritis, such as:

  • Pseudoosteoarthritis
  • Pseudogout

Arthritis of the Knee

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Causes    TOP

It is not known what causes CPPD. Genes may play a role since it can run in families.

Risk Factors    TOP

CPPD is more common in people over 50 years of age.

Other factors are:

Symptoms    TOP

In most cases, CPPD does not lead to symptoms.

If symptoms occur, they may come and go. They may happen in the knee, wrist, hand, pelvis, or hip. They may get worse over 6-24 hours.

Here are some symptoms you may have:

  • Joint pain
  • Joint stiffness, tenderness, and swelling
  • Redness over the joint

Diagnosis    TOP

You will be asked about your symptoms and health history. A physical exam will be done.

Your body fluids may be tested. This can be done with:

  • Synovial fluid analysis—taken from the joint with a needle
  • Blood tests

Images may be needed of your bodily structures. This can be done with:

Treatment    TOP

There is no cure for CPPD. The crystal deposits can’t be dissolved.

Treatment is focused on managing pain during flare-ups. Without treatment, the pain will go away on its own within days to weeks.

Talk with your doctor about the best treatment plan for you. Rest and ice may reduce pain. Here are some other methods:

Medications

Medicine may help to lower inflammation, pain, and stiffness. These are some medicines:

  • Nonsteroidal anti-inflammatory drugs (NSAIDs)
  • Corticosteroids
  • Gout medications that change the way the body reacts to the crystals, such as colchicine

Procedures

These procedures may be needed if home care and medicines do not help:

  • Arthrocentesis—to remove excess fluid and crystals
  • Corticosteroid shots—injected directly into a joint to decrease inflammation

Steroids Injected into Joint

Steroid in Knee
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Prevention    TOP

CPPD can't be prevented. The cause isn't clear.

RESOURCES:

American College of Rheumatology
http://www.rheumatology.org
National Institute of Arthritis and Musculoskeletal and Skin Diseases
http://www.niams.nih.gov

CANADIAN RESOURCES:

The Arthritis Society
http://www.arthritis.ca

References:

Calcium pyrophosphate dihydrate deposition disease. EBSCO DynaMed Plus website. Available at: http://www.dynamed.... Updated September 15, 2017. Accessed June 5, 2018.
Calcium pyrophosphate dihydrate crystal deposition disease (CPPD) (Pseudogout). The Arthritis Foundation website. Available at:
...(Click grey area to select URL)
Accessed June 5, 2018.
Calcium pyrophosphate deposition (CPPD) (formerly called pseudogout). American College of Rheumatology website. Available at: https://www.rheumatology.org/I-Am-A/Patient-Caregiver/Diseases-Conditions/Calcium-Pyrophosphate-Deposition-CPPD. Updated March 2017. Accessed June 5, 2018.
Pseudogout. Cleveland Clinic website. Available at:
...(Click grey area to select URL)
Updated December 27, 2017. Accessed June 5, 2018.
4/24/2014 DynaMed's Systematic Literature Surveillance http://www.dynamed...: Wise JN, Weissman BN, et al. American College of Radiology (ACR) Appropriateness Criteria for chronic foot pain. Available at:
...(Click grey area to select URL)
Updated 2013. Accessed June 29, 2015.
Last reviewed June 2018 by EBSCO Medical Review Board Warren A. Bodine, DO, CAQSM
Last Updated: 4/24/2014

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