Zollinger-Ellison syndrome is a rare disorder that arises from tumors and causes ulcers in the digestive system. One or more tumors form in the pancreas or duodenum (the upper part of the small intestine). Not only can these tumors lead to ulcers, they can also be cancerous, and spread to the nearby lymph nodes or liver.
About one-quarter of people with Zollinger-Ellison syndrome have a genetic disorder called multiple endocrine neoplasia type 1 (MEN 1). People with MEN 1 may have additional endocrine tumors in the brain and neck.
Zollinger-Ellison syndrome is caused by gastrin-producing tumors, called gastrinomas. Gastrin is a hormone that stimulates the stomach to produce acid. Excess acid production may lead to ulcers
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Zollinger-Ellison syndrome. EBSCO DynaMed website. Available at: ...(Click grey area to select URL) Updated March 5, 2013. Accessed August 1, 2013.
Zollinger-Ellison syndrome. National Digestive Diseases Information Clearinghouse website. Available at: ...(Click grey area to select URL) Updated May 10, 2012. Accessed August 1, 2013.