SUNDAY, Jan. 8 (HealthDay News) -- People who live 110 years or
longer have as many disease-associated genes as those in the
general population, but they may also be blessed with protective
genes that help them live so long, researchers report.
The team of U.S. scientists noted that supercentenarians, as
they are called, are extremely rare, with only one per 5 million
people in developed nations. There is growing evidence that
genetics play a major role in living to such an old age.
In what they describe as a first-of-a-kind study, the
researchers analyzed the whole genome sequences of a man and a
woman who lived past the age of 114 and found that they had as many
disease-associated genes as other people.
For example, the man had 37 genetic mutations associated with
increased risk for colon cancer.
"In fact, he had presented with an obstructing colon cancer earlier in his life that had not metastasized and was cured with surgery. He was in phenomenal cognitive and physical shape near the time of his death," study senior author Dr. Thomas Perls, director of the New England Centenarian Study, said in a Boston University Medical Center news release.
The woman had numerous genetic variations associated with
age-related disease, such as heart disease, cancer and Alzheimer's
disease. She did develop congestive heart failure and mild
cognitive impairment, but these conditions didn't become evident
until she was more than 108 years old.
"The presence of these disease-associated variants is consistent with our and other researchers' findings that centenarians carry as many disease-associated genes as the general population," Perls said. "The difference may be that the centenarians likely have longevity-associated variants that cancel out the disease genes. That effect may extend to the point that the diseases don't occur -- or, if they do, are much less pathogenic or markedly delayed towards the end of life, in these individuals who are practically living to the limit of the human lifespan."
The study was published Jan. 3 in the journal
Frontiers in Genetics, and researchers will be able to access the information at the U.S. National Institutes of Health data repository.
The American Academy of Family Physicians discusses